| | Authors | Year | No. | Mean age (range) | M : F | 5-year OS | Comments |
| | van Maldegem et al. [22] | 2019 | 34 | NA | 17 : 17 | NA | 4 centers, unresectable DDCS, positive factor: doxorubicin monotherapy | | Nemecek et al. [9] | 2018 | 33 | 62.2 (22–90) | 16 : 17 | 13.6% | 1977–2015, single center, negative factor: CRP | | Lex et al. [23] | 2018 | 31 | 55.6 (33–76) | 19 : 12 | NA | 1995–2016, pelvic DDCS, positive factor: wide surgical margin | | Dhinsa et al. [24] | 2018 | 21 | 64 (35–80) | NA | NA | 2000–2010, DDCS with osteosarcoma as predominant component, positive factor: chemotherapy | | Strotman et al. [7] | 2017 | 159 | 65.2 ± 14.7 | 83 : 76 | 18% | 2001–2011, SEER database positive factor: chest wall tumor, negative factor: size > 8 cm, metastases, no surgical resection | | Liu et al. [20] | 2017 | 23 | 50.4 (32–73) | 12 : 11 | 17.4% | 2008–2015, single center, negative factors: axial bone location, lung metastasis, inadequate surgical margin, incorrect diagnosis before surgery, and pathological fractures | | Albergo et al. [25] | 2015 | 17 | NA | NA | 6% | 1970–2012, single center, femoral DDCS negative factor: pathological fracture | | Kawaguchi et al. [8] | 2014 | 41 | 58 (26–86) | 27 : 14 | 15% | 1986–2010, single center, positive factor: ifosfamide-based adjuvant chemotherapy combined with surgical resection | | Italiano et al. [26] | 2013 | 42 | NA | NA | NA | 1988–2011, 15 centers, advanced DDCS had higher response to chemotherapy than conventional chondrosarcoma | | Yokota et al. [18] | 2012 | 9 | 58.6 (37–86) | 4 : 5 | 0% | 1996–2010, single center | | Staals et al. [27] | 2007 | 18 | 46 (22–74) | 12 : 6 | 29% | 1970–2002, single center, DDCS that arises in osteochondroma, positive factor: wide surgical resection with adjuvant chemotherapy | | Grimer et al. [6] | 2007 | 337 | Median 59 (15–89) | 179 : 158 | 24% | 1975–2005, 9 centers, negative factors: pathological fracture, pelvic location, increasing age, inadequate margins of excision | | Staals et al. [3] | 2006 | 123 | 59.2 (24–83) | 66 : 57 | 24% | 1969–2003, single center, negative factors: metastasis, MFH, high percentage of dedifferentiated component | | Bruns et al. [1] | 2005 | 13 | 59.8 (36–72) | 7 : 6 | 8% | 1990–2003, single center, surgery recommended | | Dickey et al. [17] | 2004 | 37 | 66 | 24 : 18 | 7% | 1986–2000, single center | | Mitchell et al. [5] | 2000 | 22 | 55 (17–81) | 15 : 7 | 18% | 1977–1998, single center, positive factors: chemotherapy, wide excision margins |
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CRP, C-reactive protein; DDCS, dedifferentiated chondrosarcoma; MFH, malignant fibrous histiocytoma; NA, not available; OS, overall survival; SEER, the Surveillance, Epidemiology, and End Results database.
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