A Critical Review of the Impact of Sarcoma on Psychosocial Wellbeing

Table 4

Longitudinal outcomes¹.

First author	Comparator^2	Quality of life^3	Domains^3	Mental health	Others
Davidge et al. [38]	Time: before surgery vs. after surgery	+			+ adjustment to normal life
Hinds et al. [58]	Time: diagnosis to end of treatment	+	PF, EF
Granda-Cameron et al. [54]	Time: cycles 1–8 of chemotherapy	ns
Paredes et al. [74]	Time: diagnosis to treatment	+; −	GH; PF
Paredes et al. [73]	Time: diagnosis to follow-up			=
Bekkering et al. [33]	Time: 3 to 12 months after surgery^4; 12 to 24 months after surgery^4	+; +	BT specific, PCS; PCS
Han et al. [55]	Time: before surgery to 6 months after surgery; 6 to 12 months after surgery	+; =
Paredes et al. [75]	Time: diagnosis to treatment			=
Sun et al. [95]	Time: treatment to 1 year after treatment	ns
Rivard et al. [83]	Time: before surgery vs. 12 months after surgery	+
Leiser et al. [62]	Time: treatment to 2 years after surgery	+
Bekkering et al. [108]	Time: 3 to >60 months after surgery	+	PCS
Wong et al. [105]	Time: before treatment to 5 years after treatment	ns

BT: bone tumour; EF: emotional function; GH: global health; ns: significance not specified; OS: osteosarcoma; PCS: physical component score; PF: physical function. ¹Minus (−): poorer in comparison; plus (+): better; equals (=): no difference. ²Direction of significance, i.e., better or worse, based on the first comparator, or the last time point if a longitudinal comparison. ³Result based on overall or summary scores; if these were not provided, result at domain score level was provided (QLQ-C30 functional scale only). ⁴Based on SF-36 and bone tumour-specific measure results reflecting the comparison across the whole sample.