A Critical Review of the Impact of Sarcoma on Psychosocial Wellbeing

Table 8

QOL measured by the SF-36¹.

First author	Comparator^2	Quality of life^3	Domains^3
Davis et al. [41]	AMP vs. LSS	−^5	PF
Veenstra et al. [101]	Reference values^4	−^5	PF, RP
Eiser et al. [44]	AMP vs. LSS; Reference values	=^5; −^5	PF, RP, SF, vitality, pain, GH
Malo et al. [64]	Reference values	−^5	PF, RP
Gerber et al. [51]	Reference values	=
Hopyan et al. [60]	Rotationplasty, AMP vs. LSS	=
Thijssens et al. [99]	Reference values	−^5	PF, RP
Akahane et al. [28]	Rotationplasty, AMP vs. LSS	=
Aksnes et al. [29]	Reference values; Hodgkin’s disease; Testicular cancer	−; −; −	PCS; PCS
Ginsberg et al. [52]	Rotationplasty, AMP vs. LSS	=
Bekkering et al. [34]	Reference values^7	−; +	PCS; MCS
Expósito Tirado et al. [45]	AMP vs. LSS	=
Barrera et al. [31]	AMP vs. LSS; Reference values	=^6
Bekkering et al. [33]	Time: 3 to 12 months after surgery^7; 12 to 24 months after surgery^7	+; +	BT specific, PCS; PCS
Forni et al. [49]	Reference values	−^5; +	PF; MH
Han et al. [55]	Time: before surgery to 6 months after surgery; 6 to 12 months after surgery	+; =
Sun et al. [95]	Time: treatment to 1 year after treatment; Reference values	ns; ns
Liu et al. [63]	Reference values	−
Gradl et al. [53]	Reference values	^+5	RS, MH, vitality
Rivard et al. [83]	Time: before surgery vs. 12 months after surgery	+
Shchelkova and Usmanova [91]	GCT vs. OS; GCT vs. CS	−^5; −^5	PF, MH, GH, SF; PF, SF
Fidler et al. [48]	Reference values	−
Edelmann et al. [43]	Reference values	−^5	PF, GH
Poort et al. [79]	Severe fatigue vs. none	−
Bekkering et al. [108]	AMP vs. LSS; Time: 3 to >60 months after surgery	−; +	PCS; PCS
Fernandez-Pineda et al. [47]	Reference values	−	PCS
Ranft et al. [81]	Reference values	−	PCS

AMP: amputation; BT: bone tumour; GCT: giant cell tumour; GH: global health; LSS: limb-sparing surgery; MH: mental health; ns: significance not specified; OS: osteosarcoma; PCS: physical component score; PF: physical function; RP: role-physical; RS: role-social; SF: social function. ¹Minus (−): poorer in comparison; plus (+): better; equals (=): no difference. ²Direction of significance, i.e., better or worse, based on the first comparator, or the last time point if a longitudinal comparison. ³Result based on overall or summary scores; if these were not provided, result at domain score level was provided (QLQ-C30 functional scale only). ⁴Reference values either supplied with the measure or collected from noncancer controls as part of the study. ⁵Total and/or summary scores can be calculated with the measure used, but this was not reported. ⁶Three quality of life measures used, all giving different results. ⁷Based on SF-36 and bone tumour-specific measure results reflecting the comparison across the whole sample.