Long-Term Follow-up of a Randomized Study of Oral Etoposide versus Viscum album Fermentatum Pini as Maintenance Therapy in Osteosarcoma Patients in Complete Surgical Remission after Second Relapse
Table 1
Patients characteristics.
PTS
Start TX
Age
Sex
Arm
Site/N°
T. necrosis
PgP on Met.
PRDFS
OS (ms)
Outcome
Status 30.6.19
1
08/06/07
48
F
Viscum P
Lung one
NA
NE
144
144
NED
NED
2
03/09/07
18
F
Viscum P
Lung two
PR
Pos
134
134
NED
NED
3
02/10/07
28
M
Viscum P
Lung two
GR
Pos
140
140
NED
NED
4
21/04/08
29
M
Viscum P
Lung one
GR
NA
3
17
R
Dead
5
19/09/08
30
F
Viscum P
Lung two
PR
NE
121
121
NED
NED
6
23/09/08
21
F
Viscum P
Lung three
PR
Neg
6
120
R
NED1
7
02/04/10
20
F
Viscum P
Bone one
PR
Neg
106
106
NED
NED
8
23/07/10
41
M
Viscum P
Lung one
GR
NE
2
24
R
Dead
9
30/06/11
22
M
Viscum P
Lung one
GR
Neg
11
36
R
Dead
10
12/06/07
28
M
Etoposide
Bone one
PR
NA
3
5
R
Dead
11
17/01/08
62
F
Etoposide
Lung one
GR
NA
12
128
R
NED 1
12
17/01/08
48
M
Etoposide
Lung one
PR
NE
6
134
R
NED 1
13
17/03/08
16
F
Etoposide
Lung one
GR
Neg
3
5
R
Dead
14
07/01/09
11
M
Etoposide
Lung two
GR
Neg
1
3
R
Dead
15
10/07/09
35
F
Etoposide
Lung one
NA
Neg
9
118
R
NED 1
16
28/05/09
65
M
Etoposide
Lung two
NA
Neg
84
119
R
NED 1
17
11/02/10
17
M
Etoposide
Lung two
PR
Pos
4
25
R
Dead
18
11/05/10
63
M
Etoposide
Lung one
NA
Pos
42
60
R
Dead
19
08/07/11
17
F
Etoposide
Lung two
PR
Neg
8
23
R
Dead
20
08/08/11
67
M
Etop never started ITT NA 43
NE
Dead
ITT
Site/N° = site of the 2nd metastase, N of lesions; tumor necrosis: necrosis on primary tumor; GR = good responder > 90% and PR = poor responder ≤ 90%; PgP on metastases: pos = Positive, Neg = Negative; NA = not available and NE = not evaluable; NED = nonevidence of disease after enrollment: NED1 = nonevidence of disease after treatment for a third relapse; R = relapse; ITT = intention-to-treat; PRDFS: postrelapse disease-free survival; OS: overall survival.
