Research Article

Diagnostic Differences in Expert Second-Opinion Consultation Cases at a Tertiary Sarcoma Center

Table 1

Summary of second-opinion cases received according to assigned referral and second-opinion lineage/differentiation.

Tumor categories with second-opinion diagnosesTotal no. of casesNo discrepancy in opinionDiscrepancy in opinion% with discrepancy

Specific lineage assignable
Fibroblastic/myofibroblastic99653434%
Adipocytic74423243%
Smooth muscle35251028%
Vascular32221031%
Nerve sheath32211134%
Skeletal muscle1412214%
So-called “fibrohistiocytic”2591664%
Pericytic31267%

Lesions of uncertain differentiation
Synovial sarcoma96333%
Atypical fibroxanthoma75228%
Pleomorphic hyalinizing angiectatic tumor220
Myoepithelial tumors96333%
Ossifying fibromyxoid tumor43125%
Angiomatoid fibrous histiocytoma101100%
Intramuscular myxoma101100%
Acral fibromyxoma101100%
Epithelioid sarcoma31267%
Undifferentiated pleomorphic sarcoma31161548%
Spindle cell sarcoma (including postradiation sarcoma)27131452%
Undifferentiated round cell tumor95444%
Undifferentiated malignant neoplasm2216627%
Bone and cartilage tumors/lesions74343%

Others
Follicular dendritic sarcoma220
Phyllodes tumor330
Gastrointestinal stromal tumor95444%
Specialised genital stromal tumors124866%
Olfactory neuroblastoma220
Ewing sarcoma330
Melanoma, including clear cell sarcoma2011945%
PEComa, including lymphangioleiomyomatosis330
Meningioma101100%
Mesothelioma147750%
Carcinoma33181545%
Germ cell/sex-cord stromal tumors86225%
Miscellaneous benign lesions24 = 13422 = 862 = 488%
 Total cases58136022138%