Adjuvant Radiation after Primary Resection of Atypical Lipomatous Tumors of the Extremity Reduces Local Recurrence but Increases Complications: A Multicenter Evaluation
Table 1
Patient, tumor, and treatment characteristics.
Variable
XRT n = 102
No-XRT n = 68
-value
Age, years, mean ± SD
62.1 ± 11.3
64.3 ± 12.9
0.25
Sex
0.16
Male
55 (54)
29 (43)
Female
47 (46)
39 (57)
Tumor location
0.38
Upper extremity
6 (6)
7 (10)
Lower extremity
96 (94)
61 (90)
Tumor size, cm, mean ± SD
19.2 ± 7.8
17.1 ± 7.8
0.09
MDM2 status
0.06
Positive
48 (47)
42 (62)
N/A
54 (53)
26 (38)
Tumor depth
0.35
Deep
97 (95)
62 (91)
Superficial
5 (5)
6 (9)
Tumor NVI
0.20
Yes
34 (33)
30 (44)
No
68 (67)
38 (56)
Surgical resection margins
0.08
R0/R1
101 (99)
64 (94)
R2
1 (1)
4 (6)
Treatment center
<0.001
Center 1
101 (99)
23 (34)
Center 2
1 (1)
45 (66)
Radiation dose, Gy
60.0 (55.0–66.0)
—
—
Follow-up, years
5.0 (2.7–7.0)
2.5 (1.1–7.4)
0.02
Values presented as n (%), unless otherwise specified. XRT, radiation group; No-XRT, no radiation group; SD, standard deviation; N/A, not available; NVI, neurovascular involvement; Gy, gray; , median (interquartile range).
