Research Article

Targeting the FAK-Src Complex in Desmoplastic Small Round Cell Tumors, Ewing Sarcoma, and Rhabdomyosarcoma

Table 2

Concurrent positive and high-positive pFAK and pSrc expressions in DSRCT, ES, ARMS, and ERMS tumor tissue.

Tumor typepFAKpos and pSrcpospFAKhigh and pSrchigh,a-value (pFAKpos and pSrcpos)-value (pFAKhigh and pSrchigh)

DSRCT (n = 12)8/124/80.045N.S.
ES (n = 62)4/620/40.002N.S.
ARMS (n = 20)7/203/7N.S.0.049
ERMS (n = 36)7/364/7≤0.0010.003

DSRCT: desmoplastic small round cell tumor; ES : Ewing sarcoma; ARMS: alveolar rhabdomyosarcoma; ERMS: embryonal rhabdomyosarcoma; FAK: focal adhesion kinase; a pFAKhigh and pSrchigh tumors presented as a fraction of the pFAKpos and pSrcpos group; p-value: correlation between pFAK and pSrc expression as calculated by Fisher’s exact test; N.S.: not statistically significant.