Research Article

Targeting the FAK-Src Complex in Desmoplastic Small Round Cell Tumors, Ewing Sarcoma, and Rhabdomyosarcoma

Table 3

IC50 value defactinib and dasatinib in DSRCT, ES, and RMS cell lines.

Tumor typeCell lineDefactinib (μM) (mean ± SD)Dasatinib (μM) (mean ± SD)

DSRCTJN-DSRCT-12.5 ± 1.15.4 ± 1.0
ESTC323.7 ± 0.77.7 ± 1.7
EW84.6 ± 1.96.3 ± 2.7
ARMSRh304.3 ± 0.30.6 ± 0.04
Rh414.1 ± 0.76.4 ± 0.4
ERMSRD4.5 ± 1.36.9 ± 2.9
Rh186.4 ± 1.34.8 ± 0.9

DSRCT: desmoplastic small round cell tumor; ES : Ewing sarcoma; ARMS: alveolar rhabdomyosarcoma; ERMS: embryonal rhabdomyosarcoma; SD: standard deviation