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| Case nr | Sex (M/F) | Age at diagnosis (years) | History of malignancy Y/N | Tumor site | Histology at biopsy | Histology at the time of transformation | Time first diagnosis to malignant transformation | Previous surgery before malignant transformation Y/N | Previous radiotherapy Y/N | Denosumab Y/N | Duration of denosumab | Interval start denosumab to malignant transformation | Primary or secondary malignant transformation | Clinical outcome |
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| 1 | F | 54 | Y, breast cancer | Left ilium | GCTB, H3G34W+ | High-grade osteosarcoma, H3G34W+ | 12 months | N | N | Y | 7 months | 11 months | Secondary, denosumab associated | Died 7 months after malignant diagnosis (cause unknown), lost to follow-up |
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| 2 | F | 35 | N | L2 | GCTB, H3G34W+ | Metastatic lesion in Th2: Sarcoma NOS, H3G34W+ | 92 months (from first diagnosis to development of metastasis with malignant transformation in Th2) | Y | Y | Y | 5 months | 5 months | Secondary, denosumab and surgery associated | Died 12 months after malignant diagnosis due to multiple vertebral metastases with cervicothoracic myelum compression |
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| 3 | F | 55 | N | Left femur | GCTB, H3G34W+ | High-grade osteosarcoma, H3G34W− | 23 months | Y (curettage with cement) | N | Y | 10 months | 10 months | Secondary, denosumab and surgery associated | Died 44 months after malignant diagnosis due to pulmonary metastases |
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| 4 | F | 37 | N | Left tarsal navicular | GCTB, H3G34W + | Recurrence with malignancy in GCTB (also areas with conventional GCTB). H3G34W missing | 12 months | Y (curettage, liquid nitrogen and cancellous bone graft) | N | N | NA | NA | Secondary, postsurgery | NED |
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| 5 | M | 45 | N | Sacrum | GCTB, H3G34W + | Highly suspicious for progression to malignant GCTB, H3G34W+ | 2 months | N | N | Y | 2 months, neoadjuvant to surgery | 2 months | Secondary, denosumab associated | NED |
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| 6 | F | 27 | N | Right femur | GCTB, H3G34W missing (before 2000) | Resection: low-grade sarcoma, radiation associated. H3G34W+
Amputation (2 yrs later): high-grade sarcoma, H3G34W+
En bloc resection of soft tissue recurrence in the stump (4 yrs later): high-grade sarcoma (possibly radiation associated), however H3G34W−
Intralesional resection of solitary L4 sarcoma metastasis (4.5 yrs later): H3G34W+ | 21 years | Y (multiple curettages; liquid nitrogen, cancellous bone graft and cement) | Y | N | NA | NA | Secondary, radiotherapy associated (interval 13 years) | Residual metastasis present in L4, otherwise NED |
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