Malignant Transformation of Giant Cell Tumor of Bone and the Association with Denosumab Treatment: A Radiology and Pathology Perspective

Table 3

Overview of radiological characteristics suggestive of GCTB malignant transformation, compared to baseline GCTB diagnosis.

Imaging modality	X-ray	(PET) CT	MRI
	Absent fibro-osseous matrix formation	No increased density on CT (HU) [23]
	Absent neocortex formation	Absent neocortex formation
		No decrease in SUV^max [5]
		Stable size or increase in size of the soft tissue component	Stable size or increase in size of the soft tissue component
	New cortex destruction	New cortex destruction	New cortex destruction
		New soft tissue mass	New soft tissue mass
		Metastasis (new tumor localisation)	Metastasis (new tumor localisation)

Specific to denosumab treatment.