Bone Metastases in Patients with Leiomyosarcoma: A Retrospective Analysis of Survival and Surgical Management

Table 5

Cox regression analysis of survival in 45 patients with metastatic leiomyosarcoma to the bone.

Variable	Hazard ratio (95% CI)	P
Primary LMS
Extremity soft tissue	2.5 (0.57–11)	0.23
Uterine	0.82 (0.27–2.5)	0.72
Lung	125 (5.3–2998)	0.003
H&N	0.59 (0.05–6.7)	0.67
Unknown	9.4 (1.7–52)	0.01
Location of bone metastasis^†
Appendicular	0.90 (0.11–7.6)	0.92
Axial	0.64 (0.22–1.8)	0.41
Sex^‡	1.1 (0.26–4.8)	0.88
Visceral metastases	1.5 (0.27–8.1)	0.65
Number of metastases^||	1.3 (0.33–5.5)	0.69
Pathologic fracture	5.4 (1.8–16)	0.002
Surgical management	0.41 (0.16–1.0)	0.06

Retroperitoneal; ^†metastases in axial and appendicular locations; ^‡female; ^||one metastasis.