Tumor Digital Masking Allows Precise Patient Triaging: A Study Based on Ki-67 Scoring in Gastrointestinal Stromal Tumors

Table 2

The tercile analysis for low-/moderate-/high-grade GIST according to Ki-67 HSPR%.

Characteristics	HSPR%			value
	Low (<3.5%)	Moderate (3.5%–10%)	High (≥10%)
	No. 20	No. 17	No. 20
Age (years)	61.0 (54.2–71.5)	67.0 (52.0–72.0)	57.5 (48.8–75.0)	0.63
Age (years)				0.67
≤64	11 (55.0%)	7 (41.2%)	11 (55.0%)
>64	9 (45.0%)	10 (58.8%)	9 (45.0%)
Sex				0.002
Female	15 (75.0%)	9 (52.9%)	4 (20.0%)
Male	5 (25.0%)	8 (47.1%)	16 (80.0%)
Tumor size (cm)	4.5 (2.0–6.1)	5.0 (3.5–7.0)	6.8 (4.0–7.5)	0.069
Tumor size (cm)				0.089
≤5	14 (70.0%)	10 (58.8%)	7 (35.0%)
>5	6 (30.0%)	7 (41.2%)	13 (65.0%)
Tumor location				0.58
Gastric	15 (75.0%)	13 (76.5%)	12 (60.0%)
Nongastric	5 (25.0%)	4 (23.5%)	8 (40.0%)
GIST group				0.0001
gr_1-3	19 (95.0%)	15 (88.2%)	8 (40.0%)
gr_4-6	1 (5.0%)	2 (11.8%)	12 (60.0%)
Mitotic score				0.0009
0–5	18 (90.0%)	15 (88.2%)	8 (40.0%)
>5	2 (10.0%)	2 (11.8%)	12 (60.0%)
Strong HSPR (no items per DOI)	3.0 (1.8–5.0)	115.0 (60.0–147.0)	1108.5 (181.0–3355.8)	0.007
Strong nHSPR(no items per DOI)	0.0 (0.0–1.2)	11.0 (1.0–15.0)	74.5 (28.2–995.2)	0.008
Weak HSPR(no items per DOI)	410.0 (151.0–523.2)	1180.0 (593.0–1527.0)	5608.5 (3406.0–8379.5)	<0.0001
Weak nHSPR(no items per DOI)	137.0 (37.0–350.0)	266.0 (171.0–363.0)	1760.5 (1206.2–6697.0)	0.002
nHSPR%	0.4 (0.1–0.6)	1.3 (0.8–3.0)	11.6 (3.7–24.3)	<0.0001
HSPR%_minus_nonHSPR%	0.6 (0.3–1.3)	4.1 (3.5–6.1)	11.7 (9.1–26.9)	<0.0001
Total number of cells	29166.5 (25333.8–39117.8)	19287.0 (16470.0–21826.0)	25545.0 (19779.8–31890.5)	0.002
Total number of cells				<0.0001
<25,000	5 (25.0%)	16 (94.1%)	9 (45.0%)
≥25,000	15 (75.0%)	1 (5.9%)	11 (55.0%)