The Kinetoplast of Trypanosomatids: From Early Studies of Electron Microscopy to Recent Advances in Atomic Force Microscopy

Figure 2

Schematic view of the domains found in the kinetoplast of trypanosomatids. During replication, the minicircles are released from the network into the kinetoflagellar zone, which corresponds to the region between the kDNA and the basal body and contains proteins that initiate the replication of the minicircles. The next steps of replication occur at the antipodal sites, which also contain proteins involved in kDNA duplication. The maxicircles remain attached to the network during their replication, and the details of this process are less well understood.