TY - JOUR A2 - Velligan, Dawn I. AU - Přikryl, Radovan AU - Přikrylová Kučerová, Hana AU - Vrzalová, Michaela AU - Češková, Eva PY - 2012 DA - 2012/05/07 TI - Role of Long-Acting Injectable Second-Generation Antipsychotics in the Treatment of First-Episode Schizophrenia: A Clinical Perspective SP - 764769 VL - 2012 AB - Approximately 80% of patients with the first-episode schizophrenia reach symptomatic remission after antipsychotic therapy. However, within two years most of them relapse, mainly due to low levels of insight into the illness and nonadherence to their oral medication. Therefore, although the formal data available is limited, many experts recommend prescribing long-acting injectable second-generation antipsychotics (mostly risperidone or alternatively paliperidone) in the early stages of schizophrenia, particularly in patients who have benefited from the original oral molecule in the past and agree to receive long-term injectable treatment. Early application of long-acting injectable second-generation antipsychotics can significantly reduce the risk of relapse in the future and thus improve not only the social and working potential of patients with schizophrenia but also their quality of life. SN - 2090-2085 UR - https://doi.org/10.1155/2012/764769 DO - 10.1155/2012/764769 JF - Schizophrenia Research and Treatment PB - Hindawi Publishing Corporation KW - ER -