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Study and authors | Patient sample | Results |
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Garcia-Rizo et al., 2012 [61] | Newly diagnosed patients with first-episode, nonaffective psychosis; comparison group of matched healthy controls | Significant elevation in prolactin even after controlling for confounders; more marked in women |
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Riecher-Rössler et al., 2013 [54] | 74 antipsychotic-naïve patients with first-episode psychosis | 39% of the study subjects had hyperprolactinemia |
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Warner et al., 2001 [62] | 7 drug-free male patients with schizophrenia; 7 male controls | Lower levels of bioactive prolactin in the patient group |
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Rao et al., 1984 [63] | 10 acutely ill patients with schizophrenia; 10 healthy controls | Lower levels of prolactin in patients; the authors also found lower levels of TSH and L-thyroxine |
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Kuruvilla et al., 1993 [64] | 116 patients with schizophrenia; 120 healthy controls | No difference in prolactin levels between the two groups |
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Muck-Seler et al., 2004 [65] | 20 women with schizophrenia drug-free for 7 days, compared with 25 depressed and 25 normal women | No difference in prolactin levels across the three groups |
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Rimon et al., 1981 [66] (CSF prolactin) | 28 lobotomized and 28 nonlobotomized patients with “chronic schizophrenia” | Higher CSF prolactin levels in women and in nonlobotomized patients |
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Hyyppä et al., 1980 [67] (CSF prolactin) | Lobotomized and nonlobotomized patients with “chronic schizophrenia” | Higher CSF prolactin levels in nonlobotomized patients |
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