Review Article

Prolactin and Psychopathology in Schizophrenia: A Literature Review and Reappraisal

Table 1

Studies measuring prolactin levels in schizophrenia.

Study and authorsPatient sampleResults

Garcia-Rizo et al., 2012 [61]Newly diagnosed patients with first-episode, nonaffective psychosis; comparison group of matched healthy controlsSignificant elevation in prolactin even after controlling for confounders; more marked in women

Riecher-Rössler et al., 2013 [54]74 antipsychotic-naïve patients with first-episode psychosis39% of the study subjects had hyperprolactinemia

Warner et al., 2001 [62]7 drug-free male patients with schizophrenia; 7 male controlsLower levels of bioactive prolactin in the patient group

Rao et al., 1984 [63]10 acutely ill patients with schizophrenia; 10 healthy controlsLower levels of prolactin in patients; the authors also found lower levels of TSH and L-thyroxine

Kuruvilla et al., 1993 [64]116 patients with schizophrenia; 120 healthy controlsNo difference in prolactin levels between the two groups

Muck-Seler et al., 2004 [65]20 women with schizophrenia drug-free for 7 days, compared with 25 depressed and 25 normal womenNo difference in prolactin levels across the three groups

Rimon et al., 1981 [66]
(CSF prolactin)
28 lobotomized and 28 nonlobotomized patients with “chronic schizophrenia”Higher CSF prolactin levels in women and in nonlobotomized patients

Hyyppä et al., 1980 [67]
(CSF prolactin)
Lobotomized and nonlobotomized patients with “chronic schizophrenia”Higher CSF prolactin levels in nonlobotomized patients