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Schizophrenia Research and Treatment
Volume 2014, Article ID 243907, 10 pages
http://dx.doi.org/10.1155/2014/243907
Research Article

Dimensional Information-Theoretic Measurement of Facial Emotion Expressions in Schizophrenia

Jihun Hamm,1 Amy Pinkham,2 Ruben C. Gur,3,4 Ragini Verma,5 and Christian G. Kohler3

1Department of Computer Science and Engineering, The Ohio State University, Columbus, OH 43210, USA
2Southern Methodist University, Dallas, TX 75205, USA
3Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania, Philadelphia, PA 19104, USA
4Philadelphia Veterans Administration Medical Center, Philadelphia, PA 19104, USA
5Department of Radiology, Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA 19104, USA

Received 9 July 2013; Revised 26 December 2013; Accepted 28 December 2013; Published 25 February 2014

Academic Editor: Robin Emsley

Copyright © 2014 Jihun Hamm et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Bleuler, “Dementia praecox oder die gruppe der schizophrenien,” 1911.
  2. N. C. Andreasen, The Scale for the Assessment of Negative Symptoms (SANS). The Scale for the Assessment of Positive Symptoms (SAPS), The University of Iowa, Iowa City, Iowa, USA, 1984.
  3. A. K. Malla, J. J. Takhar, R. M. G. Norman et al., “Negative symptoms in first episode non-affective psychosis,” Acta Psychiatrica Scandinavica, vol. 105, no. 6, pp. 431–439, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Mäkinen, J. Miettunen, M. Isohanni, and H. Koponen, “Negative symptoms in schizophrenia—a review,” Nordic Journal of Psychiatry, vol. 62, no. 5, pp. 334–341, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. E. F. Walker, K. E. Grimes, D. M. Davis, and A. J. Smith, “Childhood precursors of schizophrenia: facial expressions of emotion,” American Journal of Psychiatry, vol. 150, no. 11, pp. 1654–1660, 1993. View at Google Scholar · View at Scopus
  6. S. R. Kay, A. Fiszbein, and L. A. Opler, “The positive and negative syndrome scale (PANSS) for schizophrenia,” Schizophrenia Bulletin, vol. 13, no. 2, pp. 261–276, 1987. View at Google Scholar · View at Scopus
  7. P. Ekman and W. Friesen, Facial Action Coding System: Investigators Guide, Consulting Psychologists Press, Palo Alto, Calif, USA, 1978.
  8. P. Ekman and W. Friesen, Manual of the Facial Action Coding System (FACS), Consulting Psychologists Press, Palo Alto, Calif, USA, 1978.
  9. H. Berenbaum, “Posed facial expressions of emotion in schizophrenia and depression,” Psychological Medicine, vol. 22, no. 4, pp. 929–937, 1992. View at Google Scholar · View at Scopus
  10. H. Berenbaum and T. F. Oltmanns, “Emotional experience and expression in schizophrenia and depression,” Journal of Abnormal Psychology, vol. 101, no. 1, pp. 37–44, 1992. View at Publisher · View at Google Scholar · View at Scopus
  11. W. Gaebel and W. Wölwer, “Facial expressivity in the course of schizophrenia and depression,” European Archives of Psychiatry and Clinical Neuroscience, vol. 254, no. 5, pp. 335–342, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Trémeau, D. Malaspina, F. Duval et al., “Facial expressiveness in patients with schizophrenia compared to depressed patients and nonpatient comparison subjects,” American Journal of Psychiatry, vol. 162, no. 1, pp. 92–101, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. C. G. Kohler, E. A. Martin, N. Stolar et al., “Static posed and evoked facial expressions of emotions in schizophrenia,” Schizophrenia Research, vol. 105, no. 1–3, pp. 49–60, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. A. M. Kring and D. M. Sloan, “The facial expression coding system (FACES): development, validation, and utility,” Psychological Assessment, vol. 19, no. 2, pp. 210–224, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. A. M. Kring, S. L. Kerr, D. A. Smith, and J. M. Neale, “Flat affect in schizophrenia does not reflect diminished subjective experience of emotion,” Journal of Abnormal Psychology, vol. 102, no. 4, pp. 507–517, 1993. View at Publisher · View at Google Scholar · View at Scopus
  16. A. M. Kring and J. M. Neale, “Do schizophrenic patients show a disjunctive relationship among expressive, experiential, and psychophysiological components of emotion?” Journal of Abnormal Psychology, vol. 105, no. 2, pp. 249–257, 1996. View at Publisher · View at Google Scholar · View at Scopus
  17. M. A. Aghevli, J. J. Blanchard, and W. P. Horan, “The expression and experience of emotion in schizophrenia: a study of social interactions,” Psychiatry Research, vol. 119, no. 3, pp. 261–270, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. C. G. Kohler, E. A. Martin, M. Milonova et al., “Dynamic evoked facial expressions of emotions in schizophrenia,” Schizophrenia Research, vol. 105, no. 1–3, pp. 30–39, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Gottheil, C. C. Thornton, and R. V. Exline, “Appropriate and background affect in facial displays of emotion. Comparison of normal and schizophrenic males,” Archives of General Psychiatry, vol. 33, no. 5, pp. 565–568, 1976. View at Google Scholar · View at Scopus
  20. B. L. Schwartz, J. Mastropaolo, R. B. Rosse, G. Mathis, and S. I. Deutsch, “Imitation of facial expressions in schizophrenia,” Psychiatry Research, vol. 145, no. 2-3, pp. 87–94, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. K. M. Putnam and A. M. Kring, “Accuracy and intensity of posed emotional expressions in unmedicated schizophrenia patients: vocal and facial channels,” Psychiatry Research, vol. 151, no. 1-2, pp. 67–76, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Steimer-Krause, R. Krause, and G. Wagner, “Interaction regulations used by schizophrenic and psychosomatic patients: studies on facial behavior in dyadic interactions,” Psychiatry, vol. 53, no. 3, pp. 209–228, 1990. View at Google Scholar · View at Scopus
  23. K. S. Earnst, A. M. Kring, M. A. Kadar, J. E. Salem, D. A. Shepard, and P. T. Loosen, “Facial expression in schizophrenia,” Biological Psychiatry, vol. 40, no. 6, pp. 556–558, 1996. View at Publisher · View at Google Scholar · View at Scopus
  24. A. M. Kring, S. L. Kerr, and K. S. Earnst, “Schizophrenic patients show facial reactions to emotional facial expressions,” Psychophysiology, vol. 36, no. 2, pp. 186–192, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. R. M. Mattes, F. Schneider, H. Heimann, and N. Birbaumer, “Reduced emotional response of schizophrenic patients in remission during social interaction,” Schizophrenia Research, vol. 17, no. 3, pp. 249–255, 1995. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Gottheil, A. Paredes, R. V. Exline, and R. Winkelmayer, “Communication of affect in schizophrenia,” Archives of General Psychiatry, vol. 22, no. 5, pp. 439–444, 1970. View at Google Scholar · View at Scopus
  27. F. Schneider, H. Heimann, W. Himer, D. Huss, R. Mattes, and B. Adam, “Computer-based analysis of facial action in schizophrenic and depressed patients,” European Archives of Psychiatry and Clinical Neuroscience, vol. 240, no. 2, pp. 67–76, 1990. View at Google Scholar · View at Scopus
  28. B. L. Schwartz, J. Mastropaolo, R. B. Rosse, G. Mathis, and S. I. Deutsch, “Imitation of facial expressions in schizophrenia,” Psychiatry Research, vol. 145, no. 2-3, pp. 87–94, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Wolf, R. Mass, F. Kiefer, K. Wiedemann, and D. Naber, “Characterization of the facial expression of emotions in schizophrenia patients: preliminary findings with a new electromyography method,” Canadian Journal of Psychiatry, vol. 51, no. 6, pp. 335–341, 2006. View at Google Scholar · View at Scopus
  30. M. Iwase, K. Yamashita, K. Takahashi et al., “Diminished facial expression despite the existence of pleasant emotional experience in schizophrenia,” Methods and Findings in Experimental and Clinical Pharmacology, vol. 21, no. 3, pp. 189–194, 1999. View at Publisher · View at Google Scholar · View at Scopus
  31. C. E. Sison, M. Alpert, R. Fudge, and R. M. Stern, “Constricted expressiveness and psychophysiological reactivity in schizophrenia,” Journal of Nervous & Mental Disease, vol. 184, no. 10, pp. 589–597, 1996. View at Publisher · View at Google Scholar
  32. R. Verma, C. Davatzikos, J. Loughead et al., “Quantification of facial expressions using high-dimensional shape transformations,” Journal of Neuroscience Methods, vol. 141, no. 1, pp. 61–73, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Alvino, C. Kohler, F. Barrett, R. E. Gur, R. C. Gur, and R. Verma, “Computerized measurement of facial expression of emotions in schizophrenia,” Journal of Neuroscience Methods, vol. 163, no. 2, pp. 350–361, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. P. Wang, F. Barrett, E. Martin et al., “Automated video-based facial expression analysis of neuropsychiatric disorders,” Journal of Neuroscience Methods, vol. 168, no. 1, pp. 224–238, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Hamm, C. G. Kohler, R. C. Gur, and R. Verma, “Automated facial action coding system for dynamic analysis of facial expressions in neuropsychiatric disorders,” Journal of Neuroscience Methods, vol. 200, no. 2, pp. 237–256, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. C. E. Shannon, “A mathematical theory of communication,” Bell System Technical Journal, vol. 27, no. 4, Article ID 379423, pp. 623–656, 1948. View at Publisher · View at Google Scholar
  37. W. R. Garner, Uncertainty and Structure as Psychological Concepts, John Wiley & Sons, New York, NY, USA, 1962.
  38. A. T. Dittman, Interpersonal Messages of Emotion, Springer, New York, NY, USA, 1972.
  39. A. Borst and F. E. Theunissen, “Information theory and neural coding,” Nature Neuroscience, vol. 2, no. 11, pp. 947–957, 1999. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Costa, A. L. Goldberger, and C. K. Peng, “Multiscale entropy analysis of biological signals,” Physical Review E, vol. 71, no. 2, part 1, Article ID 021906, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. J. Jeong, J. C. Gore, and B. S. Peterson, “Mutual information analysis of the EEG in patients with Alzheimer's disease,” Clinical Neurophysiology, vol. 112, no. 5, pp. 827–835, 2001. View at Publisher · View at Google Scholar · View at Scopus
  42. S. H. Na, S. H. Jin, S. Y. Kim, and B. J. Ham, “EEG in schizophrenic patients: mutual information analysis,” Clinical Neurophysiology, vol. 113, no. 12, pp. 1954–1960, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. R. C. Gur, R. Sara, M. Hagendoorn et al., “A method for obtaining 3-dimensional facial expressions and its standardization for use in neurocognitive studies,” Journal of Neuroscience Methods, vol. 115, no. 2, pp. 137–143, 2002. View at Publisher · View at Google Scholar · View at Scopus
  44. W. R. Garner and H. W. Hake, “The amount of information in absolute judgments,” Psychological Review, vol. 58, no. 6, pp. 446–459, 1951. View at Publisher · View at Google Scholar · View at Scopus
  45. J. Beirlant, E. J. Dudewicz, L. Gyoerfi, and E. C. Meulen, “Nonparametric entropy estimation: an overview,” International Journal of Mathematical and Statistical Sciences, vol. 6, pp. 17–39, 1997. View at Google Scholar
  46. L. F. Kozachenko and N. N. Leonenko, “Sample estimate of the entropy of a random vector,” Problemy Peredachi Informatsii, vol. 23, no. 2, pp. 9–16, 1987. View at Google Scholar · View at Scopus
  47. M. N. Goria, N. N. Leonenko, V. V. Mergel, and P. L. N. Inverardi, “A new class of random vector entropy estimators and its applications in testing statistical hypotheses,” Journal of Nonparametric Statistics, vol. 17, no. 3, pp. 277–297, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. R. M. Mnatsakanov, N. Misra, S. Li, and E. J. Harner, “Kn-nearest neighbor estimators of entropy,” Mathematical Methods of Statistics, vol. 17, no. 3, pp. 261–277, 2008. View at Publisher · View at Google Scholar · View at Scopus
  49. J. Lin, “Divergence measures based on the Shannon entropy,” IEEE Transactions on Information Theory, vol. 37, no. 1, pp. 145–151, 1991. View at Publisher · View at Google Scholar · View at Scopus
  50. D. M. Endres and J. E. Schindelin, “A new metric for probability distributions,” IEEE Transactions on Information Theory, vol. 49, no. 7, pp. 1858–1860, 2003. View at Publisher · View at Google Scholar · View at Scopus
  51. S. Kullback and R. A. Leibler, “On Information and Sufficiency,” Annals of Mathematical Statistics, vol. 22, no. 1, pp. 79–86, 1951. View at Publisher · View at Google Scholar
  52. B. C. Ho, P. Nopoulos, M. Flaum, S. Arndt, and N. C. Andreasen, “Two-year outcome in first-episode schizophrenia: predictive value of symptoms for quality of life,” American Journal of Psychiatry, vol. 155, no. 9, pp. 1196–1201, 1998. View at Google Scholar · View at Scopus
  53. R. E. Gur, C. G. Kohler, J. D. Ragland et al., “Flat affect in schizophrenia: relation to emotion processing and neurocognitive measures,” Schizophrenia Bulletin, vol. 32, no. 2, pp. 279–287, 2006. View at Publisher · View at Google Scholar · View at Scopus