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Schizophrenia Research and Treatment
Volume 2014 (2014), Article ID 789403, 8 pages
http://dx.doi.org/10.1155/2014/789403
Research Article

Effect of a System-Oriented Intervention on Compliance Problems in Schizophrenia: A Pragmatic Controlled Trial

1The Psychiatry in the Region of Southern Denmark, Søndre, Sdr. Boulevard 29, 5000 Odense C, Denmark
2Department of Public Health, Aarhus University, 8000 Aarhus C, Denmark
3Department of Psychiatry, The Psychiatry in the Region of Southern Denmark, 5000 Odense, Denmark

Received 11 December 2013; Revised 22 April 2014; Accepted 2 May 2014; Published 2 June 2014

Academic Editor: Robin Emsley

Copyright © 2014 Hanne Skarsholm et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Lublin, J. Eberhard, and S. Levander, “Current therapy issues and unmet clinical needs in the treatment of schizophrenia: a review of the new generation antipsychotics,” International Clinical Psychopharmacology, vol. 20, no. 4, pp. 183–198, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. J. M. Kane and C. U. Correll, “Pharmacologic treatment of schizophrenia,” Dialogues in Clinical Neuroscience, vol. 12, no. 3, pp. 345–357, 2010. View at Google Scholar · View at Scopus
  3. L. Osterberg and T. Blaschke, “Adherence to medication,” New England Journal of Medicine, vol. 353, no. 5, pp. 487–497, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. D. C. Goff, M. Hill, and O. Freudenreich, “Strategies for improving treatment adherence in schizophrenia and schizoaffective disorder,” Journal of Clinical Psychiatry, vol. 71, supplement 2, pp. 20–26, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. P. S. Masand, M. Roca, M. S. Turner, and J. M. Kane, “Partial adherence to antipsychotic medication impacts the course of illness in patients with schizophrenia: a review,” Primary Care Companion to the Journal of Clinical Psychiatry, vol. 11, no. 4, pp. 147–154, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. M. S. Razali and H. Yahya, “Compliance with treatment in schizophrenia: a drug intervention program in a developing country,” Acta Psychiatrica Scandinavica, vol. 91, no. 5, pp. 331–335, 1995. View at Google Scholar · View at Scopus
  7. R. Gray, “Does patient education enhance compliance with clozapine? A preliminary investigation,” Journal of Psychiatric and Mental Health Nursing, vol. 7, no. 3, pp. 285–286, 2000. View at Google Scholar · View at Scopus
  8. C. O'Donnell, G. Donohoe, L. Sharkey et al., “Compliance therapy: a randomised controlled trial in schizophrenia,” The British Medical Journal, vol. 327, no. 7419, pp. 834–836, 2003. View at Google Scholar · View at Scopus
  9. R. Gray, T. Wykes, M. Edmonds, M. Leese, and K. Gournay, “Effect of a medication management training package for nurses on clinical outcomes for patients with schizophrenia: cluster randomised controlled trial,” The British Journal of Psychiatry, vol. 185, pp. 157–162, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Gray, M. Leese, J. Bindman et al., “Adherence therapy for people with schizophrenia: European multicentre randomised controlled trial,” The British Journal of Psychiatry, vol. 189, pp. 508–514, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Pitschel-Walz, J. Bäuml, W. Bender, R. R. Engel, M. Wagner, and W. Kissling, “Psychoeducation and compliance in the treatment of Schizophrenia: results of the Munich psychosis information project study,” Journal of Clinical Psychiatry, vol. 67, no. 3, pp. 443–452, 2006. View at Google Scholar · View at Scopus
  12. S. Maneesakorn, D. Robson, K. Gournay, and R. Gray, “An RCT of adherence therapy for people with schizophrenia in Chiang Mai, Thailand,” Journal of Clinical Nursing, vol. 16, no. 7, pp. 1302–1312, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. L. H. Beebe, K. Smith, C. Crye et al., “Telenursing intervention increases psychiatric medication adherence in schizophrenia outpatients,” Journal of the American Psychiatric Nurses Association, vol. 14, no. 3, pp. 217–224, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. T. J. Hudson, R. R. Owen, C. R. Thrush, T. L. Armitage, and P. Thapa, “Guideline implementation and patient-tailoring strategies to improve medication adherence for schizophrenia,” Journal of Clinical Psychiatry, vol. 69, no. 1, pp. 74–80, 2008. View at Google Scholar · View at Scopus
  15. D. I. Velligan, P. M. Diamond, J. Mintz et al., “The use of individually tailored environmental supports to improve medication adherence and outcomes in schizophrenia,” Schizophrenia Bulletin, vol. 34, no. 3, pp. 483–493, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. P. J. Weiden, N. R. Schooler, J. C. Weedon, A. Elmouchtari, A. Sunakawa, and S. M. Goldfinger, “A randomized controlled trial of long-acting injectable risperidone vs continuation on oral atypical antipsychotics for first-episode schizophrenia patients: initial adherence outcome,” Journal of Clinical Psychiatry, vol. 70, no. 10, pp. 1397–1406, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. S. W. C. Chan, B. Yip, S. Tso, B. S. Cheng, and W. Tam, “Evaluation of a psychoeducation program for Chinese clients with schizophrenia and their family caregivers,” Patient Education and Counseling, vol. 75, no. 1, pp. 67–76, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. K. H. Anderson, S. Ford, D. Robson, J. Cassis, C. Rodrigues, and R. Gray, “An exploratory, randomized controlled trial of adherence therapy for people with schizophrenia,” International Journal of Mental Health Nursing, vol. 19, no. 5, pp. 340–349, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Barber, “Should we consider non-compliance a medical error?” Quality and Safety in Health Care, vol. 11, no. 1, pp. 81–84, 2002. View at Google Scholar · View at Scopus
  20. P. Knudsen, H. Herborg, A. R. Mortensen, M. Knudsen, and A. Hellebek, “Preventing medication errors in community pharmacy: root-cause analysis of transcription errors,” Quality and Safety in Health Care, vol. 16, no. 4, pp. 285–290, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Gray, T. Wykes, and K. Gournay, “From compliance to concordance: a review of the literature on interventions to enhance compliance with antipsychotic medication,” Journal of Psychiatric and Mental Health Nursing, vol. 9, no. 3, pp. 277–284, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Skarsholm and B. Nielsen, “Development and implementation of an integrated care pathway for managing compliance problems in patients with schizophrenia,” International Journal of Care Pathways, vol. 16, no. 4, pp. 139–145, 2012. View at Publisher · View at Google Scholar
  23. W. Miller and S. Rollnick, Motivational Interviewing, Guilford Press, 1st edition, 2002.
  24. R. Gray and D. Robson, Concordance Skills—A Manual for Health Workers, Institute of Psychiatry at Maudsley, King's College London, University of London, London, UK, 2004.
  25. N. C. Andreasen, W. T. Carpenter Jr., J. M. Kane, R. A. Lasser, S. R. Marder, and D. R. Weinberger, “Remission in schizophrenia: proposed criteria and rationale for consensus,” The American Journal of Psychiatry, vol. 162, no. 3, pp. 441–449, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. T. P. Hogan, A. G. Awad, and R. Eastwood, “A self-report scale predictive of drug compliance in schizophrenics: reliability and discriminative validity,” Psychological Medicine, vol. 13, no. 1, pp. 177–183, 1983. View at Google Scholar · View at Scopus
  27. D. I. Velligan, Y. W. F. Lam, D. C. Glahn et al., “Defining and assessing adherence to oral antipsychotics: a review of the literature,” Schizophrenia Bulletin, vol. 32, no. 4, pp. 724–742, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. D. I. Velligan, M. Wang, P. Diamond et al., “Relationships among subjective and objective measures of adherence to oral antipsychotic medications,” Psychiatric Services, vol. 58, no. 9, pp. 1187–1192, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. W. M. Macharia, G. Leon, B. H. Rowe, B. J. Stephenson, and R. B. Haynes, “An overview of interventions to improve compliance with appointment keeping for medical services,” Journal of the American Medical Association, vol. 267, no. 13, pp. 1813–1817, 1992. View at Publisher · View at Google Scholar · View at Scopus
  30. J. P. Lacro, L. B. Dunn, C. R. Dolder, S. G. Leckband, and D. V. Jeste, “Prevalence of and risk factors for medication nonadherence in patients with schizophrenia: a comprehensive review of recent literature,” Journal of Clinical Psychiatry, vol. 63, no. 10, pp. 892–909, 2002. View at Google Scholar · View at Scopus
  31. M. Nosé, C. Barbui, and M. Tansella, “How often do patients with psychosis fail to adhere to treatment programmes? A systematic review,” Psychological Medicine, vol. 33, no. 7, pp. 1149–1160, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. J. M. Kane, “Treatment adherence and long-term outcomes,” CNS Spectrums, vol. 12, no. 10, pp. 21–26, 2007. View at Google Scholar · View at Scopus
  33. H. H. Goldman, A. E. Skodol, and T. R. Lave, “Revising axis V for DSM-IV: a review of measures of social functioning,” The American Journal of Psychiatry, vol. 149, no. 9, pp. 1148–1156, 1992. View at Google Scholar · View at Scopus
  34. D. Naber, S. Moritz, M. Lambert et al., “Improvement of schizophrenic patients' subjective well-being under atypical antipsychotic drugs,” Schizophrenia Research, vol. 50, no. 1, pp. 79–88, 2001. View at Google Scholar
  35. O. Lingjaerde, U. G. Ahlfors, P. Bech, S. J. Dencker, and K. Elgen, “The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients,” Acta Psychiatrica Scandinavica, vol. 334, pp. 1–100, 1987. View at Google Scholar · View at Scopus
  36. J. H. Ware and M. B. Hamel, “Statistics in medicine: pragmatic trials—guides to better patient care?” New England Journal of Medicine, vol. 364, no. 18, pp. 1685–1687, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. W. B. Berta and R. Baker, “Factors that impact the transfer and retention of best practices for reducing error in hospitals,” Health Care Management Review, vol. 29, no. 2, pp. 90–97, 2004. View at Google Scholar · View at Scopus
  38. R. Ilott, “Does compliance therapy improve use of antipsychotic medication?” The British Journal of Community Nursing, vol. 10, no. 11, pp. 514–519, 2005. View at Google Scholar · View at Scopus
  39. A. M. McIntosh, L. Conlon, S. M. Lawrie, and A. C. Stanfield, “Compliance therapy for schizophrenia,” Cochrane Database of Systematic Reviews, vol. 3, Article ID CD003442, 2006. View at Google Scholar · View at Scopus
  40. R. Gray, J. White, M. Schulz, and C. Abderhalden, “Enhancing medication adherence in people with schizophrenia: an international programme of research,” International Journal of Mental Health Nursing, vol. 19, no. 1, pp. 36–44, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. P. Maningat and J. L. Breslow, “Needed: pragmatic clinical trials for statin-intolerant patients,” New England Journal of Medicine, vol. 365, no. 24, pp. 2250–2251, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. P. J. Helms, ““Real world” pragmatic clinical trials: what are they and what do they tell us?” Pediatric Allergy and Immunology, vol. 13, no. 1, pp. 4–9, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. D. Price, S. D. Musgrave, L. Shepstone et al., “Leukotriene antagonists as first-line or add-on asthma-controller therapy,” New England Journal of Medicine, vol. 364, no. 18, pp. 1695–1707, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. D. A. Richards, K. Lovell, S. Gilbody et al., “Collaborative care for depression in UK primary care: a randomized controlled trial,” Psychological Medicine, vol. 38, no. 2, pp. 279–287, 2008. View at Publisher · View at Google Scholar · View at Scopus