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Schizophrenia Research and Treatment
Volume 2016 (2016), Article ID 1928747, 7 pages
Research Article

Sex Differences in Severity, Social Functioning, Adherence to Treatment, and Cognition of Adolescents with Schizophrenia

1Hospital Psiquiátrico Infantil, Mexico City, Mexico
2Arete Proyectos, Mexico City, Mexico

Received 31 March 2016; Revised 10 July 2016; Accepted 23 August 2016

Academic Editor: Veena Kumari

Copyright © 2016 Rodolfo Pérez-Garza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Previous studies have reported sex differences in the clinical presentation and outcome of adult patients with schizophrenia; the aim of present study was to compare the clinical characteristics, social functioning, adherence to treatment, and cognition of adolescents with this diagnosis in a six-month followup. Methods. A total of 87 adolescents with a DSM-IV diagnosis of schizophrenia or schizophreniform disorder were evaluated with the Positive and Negative Symptoms Scale (PANSS), the Matrics Consensus Cognitive Battery (MCCB), Personal and Social Performance Scale (PSP), and the Rating of Medication Influences (ROMI). Results. Both groups showed a similar improvement in all PANSS factors and in the PSP scores during the followup. Males better adhered to treatment. Females displayed better results in the area of social cognition (, df = 2,52, and ) and attention/vigilance (, df = 2,51, and ). Conclusions. Male and female adolescents showed similar clinical presentation and functioning but a different pattern of cognitive improvement and adherence to treatment. This trial is registered with II3/02/0811.‏