Change in Prolactin Levels in Pediatric Patients Given Antipsychotics for Schizophrenia and Schizophrenia Spectrum Disorders: A Network Meta-Analysis

Table 2

Baseline characteristics and outcome data among participants included in the trials.

Study

(ITT)

Treatment

Age, mean (SD)

Male, (%)

Caucasian, (%)

Previous antipsychotic use, (%)

Baseline PANSS score, mean (SD)

Baseline prolactin, both sexes (ng/mL), mean (SD)

Baseline prolactin, males (ng/mL), mean (SD)

Baseline prolactin, females (ng/mL), mean (SD)

Prolactin change at 6 weeks, both sexes (ng/mL), mean (SD)

Prolactin change at 6 weeks, males (ng/mL), mean (SD)

Prolactin change at 6 weeks, females (ng/mL), mean (SD)

Findling et al. 2012 [19]

Quetiapine; 400 mg/day

NR

NR

NR

Quetiapine; 800 mg/day

NR

NR

NR

Placebo

NR

NR

NR

Findling et al. 2008 [20]

Aripiprazole; 10 mg/day

NR

NR

NR

NR

NR

Aripiprazole; 30 mg/day

NR

NR

NR

NR

NR

Placebo

NR

NR

NR

NR

NR

Haas et al. 2009 [21]

Risperidone; 1–3 mg/day

NR

NR

Risperidone; 4–6 mg/day

NR

NR

Placebo

NR

NR

Kryzhanovskaya et al. 2009 [22]

Olanzapine; 2.5–20 mg/day

NR

NR

NR

NR

Placebo

NR

NR

NR

NR

Singh et al. 2011 [23]

Paliperidone; 1.5 mg/day

Paliperidone; 3–6 mg/day

Paliperidone; 6–12 mg/day

Placebo

NR: not reported; SD: standard deviation; ITT: intention to treat; PANSS: Positive and Negative Syndrome Scale [14].