Review Article

Change in Prolactin Levels in Pediatric Patients Given Antipsychotics for Schizophrenia and Schizophrenia Spectrum Disorders: A Network Meta-Analysis

Table 3

Network meta-analysis results of mean change in prolactin from baseline in the overall study population.

Placebo
31.28
(20.21, 42.38)
Risperidone
1–3 mg/day
55.06
(40.53, 69.68)
23.84
(8.31, 39.37)
Risperidone
4–6 mg/day
7.68
(0.08, 15.20)
23.66
(37.14, 10.04)
47.41
(64.00, 30.85)
Quetiapine
400 mg/day
10.40
(1.38, 19.19)
20.92
(35.20, 6.58)
44.74
(61.78, 27.61)
2.71 
(−4.37, 9.78)
Quetiapine
800 mg/day
−3.46 
(−10.01, 3.08)
34.75
(47.72, 21.94)
58.54
(74.59, 42.61)
11.17
(21.14, 1.10)
13.87
(24.90, 2.69)
Aripiprazole
10 mg/day
−6.68 
(−13.73, 0.45)
37.99
(51.14, 24.88)
61.76
(77.95, 45.53)
14.34
(24.65, 3.95)
17.05
(28.36, 5.81)
−3.22 
(−10.13, 3.71)
Aripiprazole
30 mg/day
12.09
(5.71, 18.55)
19.21
(32.00, 6.23)
42.99
(58.95, 26.96)
4.44 
(−5.51, 14.35)
1.67 
(−9.20, 12.75)
15.53
(6.40, 24.71)
18.75
(9.24, 28.34)
Olanzapine
2.5–20 mg/day
0.60 
(−9.87, 11.15)
30.67
(45.99, 15.56)
54.51
(72.43, 36.56)
−7.05 
(−20.00, 5.82)
−9.79 
(−23.40, 4.10)
4.05 
(−8.37, 16.50)
7.23 
(−5.38, 20.06)
−11.46 
(−23.78, 0.70)
Paliperidone
1.5 mg/day
19.89
(9.45, 30.41)
−11.34 
(−26.66, 3.86)
35.19
(53.27, 17.23)
12.20 
(−0.61, 25.33)
9.52 
(−4.14, 23.44)
23.33
(11.01, 35.72)
26.53
(13.94, 39.19)
7.81 
(−4.40, 20.09)
19.30
(5.72, 32.88)
Paliperidone
3–6 mg/day
19.68
(8.70, 30.58)
−11.65 
(−27.26, 3.89)
35.43
(53.78, 17.14)
12.03 
(−1.39, 25.31)
9.30 
(−4.89, 23.43)
23.15
(10.38, 35.87)
26.35
(13.40, 39.36)
7.56 
(−5.07, 20.21)
19.07
(4.96, 32.98)
−0.23 
(−14.10, 13.65)
Paliperidone
6–12 mg/day

The results of the fixed effects NMA are displayed. Data are presented as mean difference (95% credible interval). Values correspond to the mean difference in the row versus the column. Values in bold are those differences that are statistically important.