Polygenic Risk Scores for Subtyping of Schizophrenia

Table 5

A summary of subtypes classified by partially shared liability between schizophrenia and comorbid traits.

Class	# subjects (%)	Symptom improvement	Cognitive function	Laboratory test	Other clinical features
Class I	181 (39.3%)	Total symptom ↓; Positive ↓; Negative ↓	VIGILANCE ↑; PROCESSING SPEED ↑; MEMORY ↑; REASONING ↑	HDL ↓	Reference
Class II	94 (18.6%)	Total symptom ↓; Positive ↓	PROCESSING SPEED ↑	Bilirubin ↓; Uric acid ↓	Lower baseline negative symptoms, lower bilirubin and uric acid, more likely to use tobacco product
Class III	64 (12.9%)	—	VIGILANCE ↑	Phosphorus ↑
Class IV	53 (10.1%)	Negative ↓	VIGILANCE ↑; PROCESSING SPEED ↑; MEMORY ↑; REASONING ↑	Lymphocyte ↓; Neutrophils ↑	More likely to have a family history and an older age when first prescribed antipsychotic medicine, less likely to discontinue medication due to the lack of effects
Class V	90 (18.1%)	—	VIGILANCE ↑; PROCESSING SPEED ↑	HDL ↑; Calcium ↑; Phosphorus ↑; Prolactin ↑