Homocysteine in Schizophrenia: Independent Pathogenetic Factor with Prooxidant Activity or Integral Marker of Other Biochemical Disturbances?

Table 2

Spearman’s correlation coefficient of Hcy with markers of oxidative stress in the studied samples.

	Hcy patients		Hcy healthy
		level		level
GSH (μMol/l)	0.098	0.498	-0.263	0.120
SOD activity (units of activity/g Hb)	0.055	0.703	0.209	0.221
CAT activity (units of activity/g Hb)	-0.252	0.078	-0.0046	0.979
КDNPH, spontaneous oxidation (units optical density/mg protein/ml)	-0.085	0.557	-0.224	0.189
ADNPH, spontaneous oxidation (units optical density/mg protein/ml)	-0.069	0.634	0.073	0.670
КDNPH, metal-catalyzed oxidation (units optical density/mg protein/ml)	-0.050	0.730	-0.078	0.652
АDNPH, metal-catalyzed oxidation (units optical density/mg protein/ml)	-0.088	0.543	0.037	0.830
MDA (nmol/ml)	-0.150	0.298	0.381	0.022

Note: Hcy: homocysteine; GSH: reduced glutathione; SOD: superoxide dismutase; CAT: catalase; КDNPH: ketone-2,4-dinitrophenylhydrazones; АDNPH: aldehyde-2,4-dinitrophenylhydrazones; MDA: malonic dialdehyde; Me (Q1, Q3): median and interquartile range; “”: mean ± standard deviation; : Spearman’s correlation coefficient.