Oligodendrocytes in Schizophrenia
1Department of Anatomy, Southern Illinois University Carbondale, Carbondale, IL 62901, USA
2Department of Psychiatry, Mount Sinai School of Medicine, NY 10128, USA
3Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
4Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA
Oligodendrocytes in Schizophrenia
Description
Schizophrenia is a heterogeneous brain disease with disturbances in a range of human characteristics including thought, perception, emotion, drive, and behavior. Although the etiology and pathophysiology of this disease remain largely unknown, significant advances in schizophrenia research have been achieved in recent years through the use of neuroimaging, genetic, and molecular methods. There is increasing evidence from human postmortem and imaging studies showing abnormalities in the white matter of brains of patients with schizophrenia. This advance has led researchers to investigate possible roles of the myelin sheath forming cells–oligodendrocytes in the pathophysiology and treatment of schizophrenia.
We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to explore roles of oligodendrocytes in the pathophysiology and treatment of schizophrenia. Potential topics include, but are not limited to:
- White Matter changes in schizophrenia
- Oligodendrocyte abnormalities in schizophrenia
- Animal models of schizophrenia with white matter changes or experimentally induced oligodendrogliapathy
- Effects of antipsychotics on white matter
- Effects of antipsychotics on oligodendrocytes
- Central nervous system mechanisms of myelination, demyelination and remyelination
- Strategies and approaches to the treatment of white matter and oligodendroglial abnormalities in schizophrenia
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