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Stem Cells International
Volume 2010, Article ID 369578, 8 pages
http://dx.doi.org/10.4061/2010/369578
Review Article

Progenitor Cell Therapy for the Treatment of Central Nervous System Injury: A Review of the State of Current Clinical Trials

1Department of Surgery, Medical School at Houston, University of Texas, 6431 Fannin Street, MSB 5.236, Houston, TX 77030, USA
2Department of Pediatric Surgery, Medical School at Houston, University of Texas, 6431 Fannin Street, MSB 5.236, Houston, TX 77030, USA
3Department of General Surgery, Medical School at Ann Arbor, University of Michigan, Ann Arbor, MI 48109, USA
4Michael E DeBakey Institute for Comparative Cardiovascular Science and Biomedical Devices, Texas A & M University, College Station, TX 77843, USA
5Department of Neurology, Medical School at Houston, University of Texas, Houston, TX 77030, USA
6Department of Pediatric Neurosurgery, Medical School at Houston, University of Texas, Houston, TX 77030, USA

Received 11 May 2010; Accepted 10 June 2010

Academic Editor: Bruce A. Bunnell

Copyright © 2010 Peter A. Walker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. J. Thompson, “A critical analysis of measures of caregiver and family functioning following traumatic brain injury,” The Journal of Neuroscience Nursing, vol. 41, no. 3, pp. 148–158, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. H.-Y. Lee, J.-S. Hwang, J.-S. Jeng, and J.-D. Wang, “Quality-adjusted life expectancy (QALE) and loss of QALE for patients with ischemic stroke and intracerebral hemorrhage: a 13-year follow-up,” Stroke, vol. 41, no. 4, pp. 739–744, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Faul, M. M. Wald, W. Rutland-Brown, E. E. Sullivent, and R. W. Sattin, “Using a cost-benefit analysis to estimate outcomes of a clinical treatment guideline: testing the Brain Trauma Foundation guidelines for the treatment of severe traumatic brain injury,” The Journal of Trauma, vol. 63, no. 6, pp. 1271–1278, 2007. View at Google Scholar · View at Scopus
  4. T. N. Taylor, P. H. Davis, J. C. Torner, J. Holmes, J. W. Meyer, and M. F. Jacobson, “Lifetime cost of stroke in the United States,” Stroke, vol. 27, no. 9, pp. 1459–1466, 1996. View at Google Scholar · View at Scopus
  5. D. T. Scadden, “The stem-cell niche as an entity of action,” Nature, vol. 441, no. 7097, pp. 1075–1079, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. L. P. Weiner, “Definitions and criteria for stem cells,” Methods in Molecular Biology, vol. 438, pp. 3–8, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Qu, A. Mahmood, D. Lu, A. Goussev, Y. Xiong, and M. Chopp, “Treatment of traumatic brain injury in mice with marrow stromal cells,” Brain Research, vol. 1208, pp. 234–239, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. A. de Vasconcelos dos Santos, J. da Costa Reis, B. Diaz Paredes et al., “Therapeutic window for treatment of cortical ischemia with bone marrow-derived cells in rats,” Brain Research, vol. 1306, pp. 149–158, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. D.-I. Jung, J. Ha, B.-T. Kang et al., “A comparison of autologous and allogenic bone marrow-derived mesenchymal stem cell transplantation in canine spinal cord injury,” Journal of the Neurological Sciences, vol. 285, no. 1-2, pp. 67–77, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. L.-R. Zhao, W.-M. Duan, M. Reyes, C. D. Keene, C. M. Verfaillie, and W. C. Low, “Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats,” Experimental Neurology, vol. 174, no. 1, pp. 11–20, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. D. Lu, A. Mahmood, L. Wang, Y. Li, M. Lu, and M. Chopp, “Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome,” NeuroReport, vol. 12, no. 3, pp. 559–563, 2001. View at Google Scholar · View at Scopus
  12. M. Hayase, M. Kitada, S. Wakao et al., “Committed neural progenitor cells derived from genetically modified bone marrow stromal cells ameliorate deficits in a rat model of stroke,” Journal of Cerebral Blood Flow and Metabolism, vol. 29, no. 8, pp. 1409–1420, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. S.-U. Kuh, Y.-E. Cho, D.-H. Yoon, K.-N. Kim, and Y. Ha, “Functional recovery after human umbilical cord blood cells transplantation with brain-derived neutrophic factor into the spinal cord injured rat,” Acta Neurochirurgica, vol. 147, no. 9, pp. 985–992, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. R. F. Castro, K. A. Jackson, M. A. Goodell, C. S. Robertson, H. Liu, and H. D. Shine, “Failure of bone marrow cells to transdifferentiate into neural cells in vivo,” Science, vol. 297, no. 5585, p. 1299, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. A. J. Wagers, R. I. Sherwood, J. L. Christensen, and I. L. Weissman, “Little evidence for developmental plasticity of adult hematopoietic stem cells,” Science, vol. 297, no. 5590, pp. 2256–2259, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Roybon, Z. Ma, F. Asztely et al., “Failure of transdifferentiation of adult hematopoietic stem cells into neurons,” Stem Cells, vol. 24, no. 6, pp. 1594–1604, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. K. N. Kim, S. H. Oh, K. H. Lee, and D. H. Yoon, “Effect of human mesenchymal stem cell transplantation combined with growth factor infusion in the repair of injured spinal cord,” Acta Neurochirurgica. Supplement, vol. 99, pp. 133–136, 2006. View at Google Scholar · View at Scopus
  18. D. P. J. Hunt, K. A. Irvine, D. J. Webber, D. A. S. Compston, W. F. Blakemore, and S. Chandran, “Effects of direct transplantation of multipotent mesenchymal stromal/stem cells into the demyelinated spinal cord,” Cell Transplantation, vol. 17, no. 7, pp. 865–873, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. M. T. Harting, F. Jimenez, S. D. Adams, D. W. Mercer, and C. S. Cox Jr., “Acute, regional inflammatory response after traumatic brain injury: implications for cellular therapy,” Surgery, vol. 144, no. 5, pp. 803–813, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Aggarwal and M. F. Pittenger, “Human mesenchymal stem cells modulate allogeneic immune cell responses,” Blood, vol. 105, no. 4, pp. 1815–1822, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. P. A. Walker, M. T. Harting, F. Jimenez et al., “Direct intrathecal implantation of mesenchymal stromal cells leads to enhanced neuroprotection via an NFkappaB mediated increase in Interleukin 6 (IL-6) production,” Stem Cells and Development, vol. 19, no. 6, pp. 867–876, 2010. View at Google Scholar
  22. N. Liu, R. Chen, H. Du, J. Wang, Y. Zhang, and J. Wen, “Expression of IL-10 and TNF-α in rats with cerebral infarction after transplantation with mesenchymal stem cells,” Cellular and Molecular Immunology, vol. 6, no. 3, pp. 207–213, 2009. View at Google Scholar · View at Scopus
  23. C. T. Ajmo Jr., L. A. Collier, C. C. Leonardo et al., “Blockade of adrenoreceptors inhibits the splenic response to stroke,” Experimental Neurology, vol. 218, no. 1, pp. 47–55, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Vendrame, C. Gemma, K. R. Pennypacker et al., “Cord blood rescues stroke-induced changes in splenocyte phenotype and function,” Experimental Neurology, vol. 199, no. 1, pp. 191–200, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Németh, A. Leelahavanichkul, P. S. T. Yuen et al., “Bone marrow stromal cells attenuate sepsis via prostaglandin E 2-dependent reprogramming of host macrophages to increase their interleukin-10 production,” Nature Medicine, vol. 15, no. 1, pp. 42–49, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. J.-K. Yoon, B.-N. Park, W.-Y. Shim et al., “In vivo tracking of 111In-labeled bone marrow mesenchymal stem cells in acute brain trauma model,” Nuclear Medicine and Biology, vol. 37, no. 3, pp. 381–388, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. O. Detante, A. Moisan, J. Dimastromatteo et al., “Intravenous administration of 99mTc-HMPAO-labeled human mesenchymal stem cells after stroke: in vivo imaging and biodistribution,” Cell Transplantation, vol. 18, no. 12, pp. 1369–1379, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Vilalta, I. R. Dégano, J. Bagó et al., “Biodistribution, long-term survival, and safety of human adipose tissue-derived mesenchymal stem cells transplanted in nude mice by high sensitivity non-invasive bioluminescence imaging,” Stem Cells and Development, vol. 17, no. 5, pp. 993–1003, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. S.-K. Kang, M.-J. Shin, J. S. Jung, Y. G. Kim, and C.-H. Kim, “Autologous adipose tissue-derived stromal cells for treatment of spinal cord injury,” Stem Cells and Development, vol. 15, no. 4, pp. 583–594, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. U. M. Fischer, M. T. Harting, F. Jimenez et al., “Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect,” Stem Cells and Development, vol. 18, no. 5, pp. 683–691, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. Prevention CfDCa, “From the Centers for Disease Control and Prevention. Prevalence of disabilities and associated health conditions among adults—United States, 1999,” Journal of the American Medical Association, vol. 285, no. 12, pp. 1571–1572, 2001. View at Google Scholar · View at Scopus
  32. Stroke TNIoNDa, “Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group,” The New England Journal of Medicine, vol. 333, no. 24, pp. 1581–1587, 1995. View at Google Scholar
  33. H. Shichinohe, S. Kuroda, S. Yano, K. Hida, and Y. Iwasaki, “Role of SDF-1/CXCR4 system in survival and migration of bone marrow stromal cells after transplantation into mice cerebral infarct,” Brain Research, vol. 1183, no. 1, pp. 138–147, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Abe, “Therapeutic potential of neurotrophic factors and neural stem cells against ischemic brain injury,” Journal of Cerebral Blood Flow and Metabolism, vol. 20, no. 10, pp. 1393–1408, 2000. View at Google Scholar · View at Scopus
  35. G. Amabile and A. Meissner, “Induced pluripotent stem cells: current progress and potential for regenerative medicine,” Trends in Molecular Medicine, vol. 15, no. 2, pp. 59–68, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Chopp and Y. Li, “Treatment of stroke and intracerebral hemorrhage with cellular and pharmacological restorative therapies,” Acta Neurochirurgica. Supplement, vol. 105, pp. 79–83, 2008. View at Google Scholar · View at Scopus
  37. M. Brenneman, S. Sharma, M. Harting et al., “Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats,” Journal of Cerebral Blood Flow and Metabolism, vol. 30, no. 1, pp. 140–149, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. J. L. Saver, G. W. Albers, B. Dunn, K. C. Johnston, and M. Fisher, “Stroke therapy academic industry roundtable (STAIR) recommendations for extended window acute stroke therapy trials,” Stroke, vol. 40, no. 7, pp. 2594–2600, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. C. S. J. Cox, J. E. Baumgartner, M. T. Harting et al., “Autologous bone marrow mononculear cell therapy for severe traumatic brain injury in children,” Neurosurgery. In press.
  40. E. Syková, P. Jendelová, L. Urdzíková, P. Lesný, and A. Hejčl, “Bone marrow stem cells and polymer hydrogels—two strategies for spinal cord injury repair,” Cellular and Molecular Neurobiology, vol. 26, no. 7-8, pp. 1113–1129, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. A. F. Cristante, T. E. P. Barros-Filho, N. Tatsui et al., “Stem cells in the treatment of chronic spinal cord injury: evaluation of somatosensitive evoked potentials in 39 patients,” Spinal Cord, vol. 47, no. 10, pp. 733–738, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. F. Callera and R. X. do Nascimento, “Delivery of autologous bone marrow precursor cells into the spinal cord via lumbar puncture technique in patients with spinal cord injury: a preliminary safety study,” Experimental Hematology, vol. 34, no. 2, pp. 130–131, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. F. Callera and C. M. T. P. de Melo, “Magnetic resonance tracking of magnetically labeled autologous bone marrow CD34+ cells transplanted into the spinal cord via lumbar puncture technique in patients with chronic spinal cord injury: CD34+ cells' migration into the injured site,” Stem Cells and Development, vol. 16, no. 3, pp. 461–466, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. H. Deda, M. C. Inci, A. E. Kurekçi et al., “Treatment of chronic spinal cord injured patients with autologous bone marrow-derived hematopoietic stem cell transplantation: 1-year follow-up,” Cytotherapy, vol. 10, no. 6, pp. 565–574, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. S. H. Yoon, Y. S. Shim, Y. H. Park et al., “Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: phase I/II clinical trial,” Stem Cells, vol. 25, no. 8, pp. 2066–2073, 2007. View at Publisher · View at Google Scholar · View at Scopus
  46. N. Amariglio, A. Hirshberg, B. W. Scheithauer et al., “Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient,” PLoS Medicine, vol. 6, no. 2, Article ID e1000029, 2009. View at Publisher · View at Google Scholar · View at Scopus