Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2010, Article ID 582382, 5 pages
http://dx.doi.org/10.4061/2010/582382
Research Article

Cotransplantation of Adipose Tissue-Derived Insulin-Secreting Mesenchymal Stem Cells and Hematopoietic Stem Cells: A Novel Therapy for Insulin-Dependent Diabetes Mellitus

1Department of Pathology, Laboratory of Medicine, Transfusion Services and Immunohematology, Dr. H. L. Trivedi Institute of Transplantation Sciences, India
2Department of Nephrology and Transplantation Medicine, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Centre (IKDRC), India
3Dr. H. L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Gujarat, Ahmedabad 380016, India

Received 1 April 2010; Revised 10 June 2010; Accepted 25 November 2010

Academic Editor: Bruce A. Bunnell

Copyright © 2010 A. V. Vanikar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. K. Mehra, N. Kumar, G. Kaur, U. Kanga, and N. Tandon, “Biomarkers of susceptibility to type 1 diabetes with special reference to the Indian population,” Indian Journal of Medical Research, vol. 125, no. 3, pp. 321–344, 2007. View at Google Scholar · View at Scopus
  2. D. M. Nathan, “Long-term complications of diabetes mellitus,” The New England Journal of Medicine, vol. 328, no. 23, pp. 1676–1685, 1993. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. R. R. Rubin and M. Peyrot, “Quality of life and diabetes,” Diabetes/Metabolism Research and Reviews, vol. 15, no. 3, pp. 205–218, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. J. C. Voltarelli, C. E. B. Couri, A. B. P. L. Stracieri et al., “Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus,” Journal of the American Medical Association, vol. 297, no. 14, pp. 1568–1576, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. K. Timper, D. Sebok, M. Eberhardt et al., “Human adipose-tissue derived mesenchymal stem cells differentiate in to insulin, somatostatin and glucagons expressing cells,” Science, vol. 341, pp. 1135–1140, 2006. View at Google Scholar
  6. A. Schäffler and C. Büchler, “Concise review: adipose tissue-derived stromal cells—basic and clinical implications for novel cell-based therapies,” Stem Cells, vol. 25, no. 4, pp. 818–827, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. H. Trivedi, V. Shah, P. Shah et al., “High dose DBMC associated tolerance in live-related renal allograft recipients,” Transplantation Proceedings, vol. 32, no. 7, pp. 2001–2002, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. D. Q. Tang, LI. Z. Cao, B. R. Burkhardt et al., “In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow,” Diabetes, vol. 53, no. 7, pp. 1721–1732, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. P. A. Zuk, M. Zhu, P. Ashjian et al., “Human adipose tissue is a source of multipotent stem cells,” Molecular Biology of the Cell, vol. 13, no. 12, pp. 4279–4295, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. R. Yañez, M. L. Lamana, J. García-Castro, I. Colmenero, M. Ramírez, and J. A. Bueren, “Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease,” Stem Cells, vol. 24, no. 11, pp. 2582–2591, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. H. L. Trivedi, A. V. Vanikar, U. Thakker et al., “Human adipose tissue-derived mesenchymal stem cells combined with hematopoietic stem cell transplantation synthesize insulin,” Transplantation Proceedings, vol. 40, no. 4, pp. 1135–1139, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. Q. Zhou, J. Brown, A. Kanarek, J. Rajagopal, and D. A. Melton, “In vivo reprogramming of adult pancreatic exocrine cells to β-cells,” Nature, vol. 455, no. 7213, pp. 627–632, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus