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Stem Cells International
Volume 2010, Article ID 824876, 7 pages
Review Article

Tissue-Derived Stem and Progenitor Cells

Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7211, USA

Received 6 March 2009; Revised 6 July 2009; Accepted 31 August 2009

Academic Editor: Anthony Atala

Copyright © 2010 Leora J. Tesche and David A. Gerber. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The characterization and isolation of various stem cell populations, from embryonic through tissue-derived stem cells, have led a rapid growth in the field of stem cell research. These research efforts have often been interrelated as to the markers that identify a select cell population are frequently analyzed to determine their expression in cells of distinct organs/tissues. In this review, we will expand the current state of research involving select tissue-derived stem cell populations including the liver, central nervous system, and cardiac tissues as examples of the success and challenges in this field of research. Lastly, the challenges of clinical therapies will be discussed as it applies to these unique cell populations.