Fibroblast Growth Factor-2 Enhances Expansion of Human Bone Marrow-Derived Mesenchymal Stromal Cells without Diminishing Their Immunosuppressive Potential

Figure 4

Effect of PBMC and IL-1β stimulation on the immunosuppressive activity of hMSCs. Immunosuppressive activity (mean ± standard deviation; 𝑛=10; 5 control and 5 FGF-treated) of medium conditioned by MSCs from different passages stimulated with PBMCs (black bars) or IL-1β (white bars). Values are expressed as percent inhibition relative to the internal controls. Higher bars indicate higher immunosuppressive activity. Asterisks indicate significant differences in one-tail paired t-test; ^∗𝑃<.05.