Review Article

Potential Clinical Applications for Human Pluripotent Stem Cell-Derived Blood Components

Figure 1

Simplified schematic of hematopoietic differentiation. At the top, hESCs and/or iPSCs may be able to recapitulate hematopoietic differentiation in vitro after initial differentiation into EBs and/or HBs intermediates. These culture-based intermediates differentiate into cells similar to mesoderm-derived HSC/progenitors. The boxed region shows hematopoietic differentiation as it is thought to occur in vivo. HSCs undergo successive stages of differentiation to give rise to progenitor cells in both the myeloid lineage (left side) and lymphoid lineage (right side). These progenitors will undergo further differentiation to eventually give rise to mature cells within the peripheral blood.
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