Review Article
“Humanized” Stem Cell Culture Techniques: The Animal Serum Controversy
Table 3
Protein precursors abundant in UCBS and their possible functions in in vitro MSC-culture.
| S. no. | Protein precursor | In Vitro effects on hMSCs |
| (1) | Alpha-2-macroglobulin precursor | (i) Natural protease inhibitor | (ii) Role in cell regulation and differentiation |
| (2) | Apolipoprotein B-100 precursor | (i) Cholesterol transporter activity, |
| (3) | Complement C3 precursor | (i) Positive regulation of VEGF production | (ii) G-protein coupled receptor protein signaling pathway | (iii) Natural protease inhibitor |
| (4) | Complement C5 precursor | (i) Chemotaxis, positive regulation of VEGF production | (ii) Natural protease inhibitor | (iii) G-protein coupled receptor protein signaling pathway | (iv) Positive regulation of chemokine production |
| (5) | Isoform 1 of complement factor H precursor | (i) Negative regulation of complement C3 |
|
|