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Stem Cells International
Volume 2011, Article ID 570125, 10 pages
http://dx.doi.org/10.4061/2011/570125
Review Article

Preclinical Studies on Mesenchymal Stem Cell-Based Therapy for Growth Plate Cartilage Injury Repair

1School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, City East Campus, G.P.O Box 2471, Adelaide, SA 5001, Australia
2Discipline of Physiology, School of Medical Sciences, University of Adelaide, Adelaide, SA 5005, Australia
3Department of Orthopaedic Surgery, Women's and Children's Hospital, North Adelaide, SA 5006, Australia

Received 15 March 2011; Accepted 7 June 2011

Academic Editor: Shinn-Chih Wu

Copyright © 2011 Rosa Chung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. P. Iannotti, “Growth plate physiology and pathology,” Orthopedic Clinics of North America, vol. 21, no. 1, pp. 1–17, 1990. View at Google Scholar · View at Scopus
  2. X. Yang and G. Karsenty, “Transcription factors in bone: developmental and pathological aspects,” Trends in Molecular Medicine, vol. 8, no. 7, pp. 340–345, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. C. J. Xian, “Roles of epidermal growth factor family in the regulation of postnatal somatic growth,” Endocrine Reviews, vol. 28, no. 3, pp. 284–296, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. G. J. Tortora and S. R. Grabowski, Principles of Anatomy and Physiology, John Wiley & Sons, New York, NY, USA, 2000.
  5. S. Provot and E. Schipani, “Molecular mechanisms of endochondral bone development,” Biochemical and Biophysical Research Communications, vol. 328, no. 3, pp. 658–665, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. I. E. Jones, S. M. Williams, N. Dow, and A. Goulding, “How many children remain fracture-free during growth? A longitudinal study of children and adolescents participating in the dunedin multidisciplinary health and development study,” Osteoporosis International, vol. 13, no. 12, pp. 990–995, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. T. Mizuta, W. M. Benson, B. K. Foster, D. C. Paterson, and L. L. Morris, “Statistical analysis of the incidence of physeal injuries,” Journal of Pediatric Orthopaedics, vol. 7, no. 5, pp. 518–523, 1987. View at Google Scholar · View at Scopus
  8. J. H. Brown and S. A. DeLuca, “Growth plate injuries: Salter-Harris classification,” American Family Physician, vol. 46, no. 4, pp. 1180–1184, 1992. View at Google Scholar · View at Scopus
  9. R. B. Salter and W. R. Harris, “Injuries involving the epiphyseal plate,” Journal of Bone and Joint Surgery, vol. 45, pp. 587–622, 1963. View at Google Scholar · View at Scopus
  10. J. T. Leary, M. Handling, M. Talerico, L. Yong, and J. A. Bowe, “Physeal fractures of the distal tibia: predictive factors of premature physeal closure and growth arrest,” Journal of Pediatric Orthopaedics, vol. 29, no. 4, pp. 356–361, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. R. M. Kay and G. A. Matthys, “Pediatric ankle fractures: evaluation and treatment,” The Journal of the American Academy of Orthopaedic Surgeons, vol. 9, no. 4, pp. 268–278, 2001. View at Google Scholar · View at Scopus
  12. S. J. Mubarak, J. R. Kim, E. W. Edmonds, M. E. Pring, and T. P. Bastrom, “Classification of proximal tibial fractures in children,” Journal of Children's Orthopaedics, vol. 3, no. 3, pp. 191–197, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. C. J. Basener, C. T. Mehlman, and T. G. DiPasquale, “Growth disturbance after distal femoral growth plate fractures in children: a meta-analysis,” Journal of Orthopaedic Trauma, vol. 23, no. 9, pp. 663–667, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. A. Barmada, T. Gaynor, and S. J. Mubarak, “Premature physeal closure following distal tibia physeal fractures: a new radiographic predictor,” Journal of Pediatric Orthopaedics, vol. 23, no. 6, pp. 733–739, 2003. View at Google Scholar · View at Scopus
  15. J. A. Ogden, “Growth slowdown and arrest lines,” Journal of Pediatric Orthopaedics, vol. 4, no. 4, pp. 409–415, 1984. View at Google Scholar · View at Scopus
  16. J. M. Wattenbarger, H. E. Gruber, and L. S. Phieffer, “Physeal fractures, part I: histologic features of bone, cartilage, and bar formation in a small animal model,” Journal of Pediatric Orthopaedics, vol. 22, no. 6, pp. 703–709, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Tobita, M. Ochi, Y. Uchio et al., “Treatment of growth plate injury with autogenous chondrocytes: a study in rabbits,” Acta Orthopaedica Scandinavica, vol. 73, no. 3, pp. 352–358, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. J. H. P. Hui, H. W. Ouyang, D. W. Hutmacher, J. C. H. Goh, and E. H. Lee, “Mesenchymal stem cells in musculoskeletal tissue engineering: a review of recent advances in National University of Singapore,” Annals of the Academy of Medicine Singapore, vol. 34, no. 2, pp. 206–212, 2005. View at Google Scholar · View at Scopus
  19. A. L. Johnson, “Treatment of growth deformities with external skeletal fixation,” Veterinary Clinics of North America, vol. 22, no. 1, pp. 209–223, 1992. View at Google Scholar · View at Scopus
  20. B. K. Foster and E. W. Johnstone, “Management of growth plate injuries,” in Paediatric Orthopaedics and Fractures, M. Benson, J. Fixsen, M. MacNicol, and K. Parsch, Eds., Harcourt, London, UK, 2000. View at Google Scholar
  21. F. Sailhan, F. Chotel, A. L. Guibal et al., “Three-dimensional MR imaging in the assessment of physeal growth arrest,” European Radiology, vol. 14, no. 9, pp. 1600–1608, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. C. J. Xian and B. K. Foster, “The biological aspects of children's fractures,” in Fractures in Children, J. Beaty and J. Kasser, Eds., pp. 21–50, Philadelphia, Pa, USA, Lippincott Williams and Wilkins, 2006. View at Google Scholar
  23. H. A. Peterson, “Partial growth plate arrest and its treatment,” Journal of Pediatric Orthopaedics, vol. 4, no. 2, pp. 246–258, 1984. View at Google Scholar · View at Scopus
  24. S. H. Bostock and B. G. S. Peach, “Spontaneous resolution of an osseous bridge affecting the distal tibial epiphysis,” Journal of Bone and Joint Surgery. British, vol. 78, no. 4, pp. 662–663, 1996. View at Google Scholar · View at Scopus
  25. D. Paley, J. E. Herzenberg, G. Paremain, and A. Bhave, “Femoral lengthening over an intramedullary nail. A matched-case comparison with ilizarov femoral lenghtening,” Journal of Bone and Joint Surgery. American, vol. 79, no. 10, pp. 1464–1480, 1997. View at Google Scholar · View at Scopus
  26. M. T. Dahl, B. Gulli, and T. Berg, “Complications of limb lengthening. A learning curve,” Clinical Orthopaedics and Related Research, no. 301, pp. 10–18, 1994. View at Google Scholar · View at Scopus
  27. R. Baumgart, “The reverse planning method for lengthening of the lower limb using a straight intramedullary nail with or without deformity correction. A new method,” Operative Orthopadie und Traumatologie, vol. 21, no. 2, pp. 221–233, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. A. Langenskiold, “Surgical treatment of partial closure of the growth plate,” Journal of Pediatric Orthopaedics, vol. 1, no. 1, pp. 3–11, 1981. View at Google Scholar · View at Scopus
  29. M. Brittberg, “Autologous chondrocyte implantation—technique and long-term follow-up,” Injury, vol. 39, supplement 1, pp. 40–49, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. W. Richter, “Mesenchymal stem cells and cartilage in situ regeneration,” Journal of Internal Medicine, vol. 266, no. 4, pp. 390–405, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. B. C. Toolan, S. R. Frenkel, D. S. Pereira, and H. Alexander, “Development of a novel osteochondral graft for cartilage repair,” Journal of Biomedical Materials Research, vol. 41, no. 2, pp. 244–250, 1998. View at Publisher · View at Google Scholar · View at Scopus
  32. A. J. Detterline, S. Goldberg, B. R. Bach Jr., and B. J. Cole, “Treatment options for articular cartilage defects of the knee,” Orthopaedic Nursing, vol. 24, no. 5, pp. 361–368, 2005. View at Google Scholar · View at Scopus
  33. Y. Miura, J. Parvizi, J. S. Fitzsimmons, and S. W. O'Driscoll, “Brief exposure to high-dose transforming growth factor-beta1 enhances periosteal chondrogenesis in vitro: a preliminary report,” Journal of Bone and Joint Surgery. American, vol. 84, no. 5, pp. 793–799, 2002. View at Google Scholar · View at Scopus
  34. G. Bentley and R. B. Greer III, “Homotransplantation of isolated epiphyseal and articular cartilage chondrocytes into joint surfaces of rabbits,” Nature, vol. 230, no. 5293, pp. 385–388, 1971. View at Publisher · View at Google Scholar · View at Scopus
  35. A. L. Hansen, B. K. Foster, G. J. Gibson, G. F. Binns, O. W. Wiebkin, and J. J. Hopwood, “Growth-plate chondrocyte cultures for reimplantation into growth-plate defects in sheep. Characterization of cultures,” Clinical Orthopaedics and Related Research, no. 256, pp. 286–298, 1990. View at Google Scholar · View at Scopus
  36. C. Vinatier, D. Mrugala, C. Jorgensen, J. Guicheux, and D. Noel, “Cartilage engineering: a crucial combination of cells, biomaterials and biofactors,” Trends in Biotechnology, vol. 27, no. 5, pp. 307–314, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. G. Outka, “The ethics of embryonic stem cell research and the principle of ‘nothing is lost’,” Yale Journal of Health Policy, Law, and Ethics, vol. 9, supplement 1, pp. 585–602, 2009. View at Google Scholar · View at Scopus
  38. Y. A. Romanov, A. N. Darevskaya, N. V. Merzlikina, and L. B. Buravkova, “Mesenchymal stem cells from human bone marrow and adipose tissue: isolation, characterization, and differentiation potentialities,” Bulletin of Experimental Biology and Medicine, vol. 140, no. 1, pp. 138–143, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. A. I. Caplan, “Mesenchymal stem cells,” Journal of Orthopaedic Research, vol. 9, no. 5, pp. 641–650, 1991. View at Google Scholar · View at Scopus
  40. D. J. Prockop, “Marrow stromal cells as stem cells for nonhematopoietic tissues,” Science, vol. 276, no. 5309, pp. 71–74, 1997. View at Publisher · View at Google Scholar · View at Scopus
  41. K. Nakamura, T. Shirai, S. Morishita, S. Uchida, K. Saeki-Miura, and F. Makishima, “p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells,” Experimental Cell Research, vol. 250, no. 2, pp. 351–363, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  42. T. Fukumoto, J. W. Sperling, A. Sanyal et al., “Combined effects of insulin-like growth factor-1 and transforming growth factor-beta1 on periosteal mesenchymal cells during chondrogenesis in vitro,” Osteoarthritis and Cartilage, vol. 11, no. 1, pp. 55–64, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. S. W. O'Driscoll and J. S. Fitzsimmons, “The role of periosteum in cartilage repair,” Clinical Orthopaedics and Related Research, supplement 391, pp. S190–S207, 2001. View at Google Scholar · View at Scopus
  44. U. Noth, A. M. Osyczka, R. Tuli, N. J. Hickok, K. G. Danielson, and R. S. Tuan, “Multilineage mesenchymal differentiation potential of human trabecular bone-derived cells,” Journal of Orthopaedic Research, vol. 20, no. 5, pp. 1060–1069, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  45. V. Sottile, C. Halleux, F. Bassilana, H. Keller, and K. Seuwen, “Stem cell characteristics of human trabecular bone-derived cells,” Bone, vol. 30, no. 5, pp. 699–704, 2002. View at Publisher · View at Google Scholar · View at Scopus
  46. J. L. Dragoo, B. Samimi, M. Zhu et al., “Tissue-engineered cartilage and bone using stem cells from human infrapatellar fat pads,” Journal of Bone and Joint Surgery. British, vol. 85, no. 5, pp. 740–747, 2003. View at Google Scholar · View at Scopus
  47. H. A. Awad, M. Q. Wickham, H. A. Leddy, J. M. Gimble, and F. Guilak, “Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds,” Biomaterials, vol. 25, no. 16, pp. 3211–3222, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  48. B. Peterson, J. Zhang, R. Iglesias et al., “Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue,” Tissue Engineering, vol. 11, no. 1-2, pp. 120–129, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  49. R. J. Jankowski, B. M. Deasy, and J. Huard, “Muscle-derived stem cells,” Gene Therapy, vol. 9, no. 10, pp. 642–647, 2002. View at Publisher · View at Google Scholar · View at Scopus
  50. B. M. Deasy, R. J. Jankowski, and J. Huard, “Muscle-derived stem cells: characterization and potential for cell-mediated therapy,” Blood Cells, Molecules, and Diseases, vol. 27, no. 5, pp. 924–933, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  51. F. P. Barry and J. M. Murphy, “Mesenchymal stem cells: clinical applications and biological characterization,” International Journal of Biochemistry and Cell Biology, vol. 36, no. 4, pp. 568–584, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  52. C. De Bari, F. Dell'Accio, F. Vandenabeele, J. R. Vermeesch, J. M. Raymackers, and F. P. Luyten, “Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane,” Journal of Cell Biology, vol. 160, no. 6, pp. 909–918, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  53. C. De Bari, F. Dell'Accio, P. Tylzanowski, and F. P. Luyten, “Multipotent mesenchymal stem cells from adult human synovial membrane,” Arthritis and Rheumatism, vol. 44, no. 8, pp. 1928–1942, 2001. View at Publisher · View at Google Scholar · View at Scopus
  54. C. J. Xian and B. K. Foster, “Repair of injured articular and growth plate cartilage using mesenchymal stem cells and chondrogenic gene therapy,” Current Stem Cell Research and Therapy, vol. 1, no. 2, pp. 213–229, 2006. View at Publisher · View at Google Scholar · View at Scopus
  55. J. Park, K. Gelse, S. Frank, K. von der Mark, T. Aigner, and H. Schneider, “Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cells,” Journal of Gene Medicine, vol. 8, no. 1, pp. 112–125, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  56. A. I. Caplan, “The mesengenic process,” Clinics in Plastic Surgery, vol. 21, no. 3, pp. 429–435, 1994. View at Google Scholar · View at Scopus
  57. K. W. Liechty, T. C. Mackenzie, A. F. Shaaban et al., “Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep,” Nature Medicine, vol. 6, no. 11, pp. 1282–1286, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  58. J. J. Choi, S. A. Yoo, S. J. Park et al., “Mesenchymal stem cells overexpressing interleukin-10 attenuate collagen-induced arthritis in mice,” Clinical and Experimental Immunology, vol. 153, no. 2, pp. 269–276, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  59. U. Noth, A. F. Steinert, and R. S. Tuan, “Technology insight: adult mesenchymal stem cells for osteoarthritis therapy,” Nature Clinical Practice Rheumatology, vol. 4, no. 7, pp. 371–380, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  60. X. Chen, M. A. Armstrong, and G. Li, “Mesenchymal stem cells in immunoregulation,” Immunology and Cell Biology, vol. 84, no. 5, pp. 413–421, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  61. A. Uccelli, V. Pistoia, and L. Moretta, “Mesenchymal stem cells: a new strategy for immunosuppression?” Trends in Immunology, vol. 28, no. 5, pp. 219–226, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  62. I. Kan, E. Melamed, and D. Offen, “Autotransplantation of bone marrow-derived stem cells as a therapy for neurodegenerative diseases,” Handbook of Experimental Pharmacology, no. 180, pp. 219–242, 2007. View at Google Scholar · View at Scopus
  63. F. Chen, J. H. P. Hui, W. K. Chan, and E. H. Lee, “Cultured mesenchymal stem cell transfers in the treatment of partial growth arrest,” Journal of Pediatric Orthopaedics, vol. 23, no. 4, pp. 425–429, 2003. View at Publisher · View at Google Scholar · View at Scopus
  64. L. Planka, P. Gal, H. Kecova et al., “Allogeneic and autogenous transplantations of MSCs in treatment of the physeal bone bridge in rabbits,” BMC Biotechnology, vol. 8, article 70, 2008. View at Publisher · View at Google Scholar · View at PubMed
  65. L. Planka, A. Necas, R. Srnec et al., “Use of allogenic stem cells for the prevention of bone bridge formation in miniature pigs,” Physiological Research, vol. 58, no. 6, pp. 885–893, 2009. View at Google Scholar · View at Scopus
  66. E. B. Hunziker, I. M. K. Driesang, and E. A. Morris, “Chondrogenesis in cartilage repair is induced by members of the transforming growth factor-beta superfamily,” Clinical Orthopaedics and Related Research, supplement 391, pp. s171–s181, 2001. View at Google Scholar · View at Scopus
  67. R. Chung, B. K. Foster, A. C. W. Zannettino, and C. J. Xian, “Potential roles of growth factor PDGF-BB in the bony repair of injured growth plate,” Bone, vol. 44, no. 5, pp. 878–885, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  68. L. A. Solchaga, K. Penick, J. D. Porter, V. M. Goldberg, A. I. Caplan, and J. F. Welter, “FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells,” Journal of Cellular Physiology, vol. 203, no. 2, pp. 398–409, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  69. N. Indrawattana, G. Chen, M. Tadokoro et al., “Growth factor combination for chondrogenic induction from human mesenchymal stem cell,” Biochemical and Biophysical Research Communications, vol. 320, no. 3, pp. 914–919, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  70. Q. O. Tang, K. Shakib, M. Heliotis et al., “TGF-beta3: a potential biological therapy for enhancing chondrogenesis,” Expert Opinion on Biological Therapy, vol. 9, no. 6, pp. 689–701, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  71. J. I. Ahn, S. T. Canale, S. D. Butler, and K. A. Hasty, “Stem cell repair of physeal cartilage,” Journal of Orthopaedic Research, vol. 22, no. 6, pp. 1215–1221, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  72. R. C. McCarty, C. J. Xian, S. Gronthos, A. C. Zannettino, and B. K. Foster, “Application of autologous bone marrow derived mesenchymal stem cells to an ovine model of growth plate cartilage injury,” The Open Orthopaedics Journal, vol. 4, pp. 204–210, 2010. View at Google Scholar
  73. J. H. Jeong, E. S. Jin, J. K. Min et al., “Human mesenchymal stem cells implantation into the degenerated coccygeal disc of the rat,” Cytotechnology, vol. 59, no. 1, pp. 55–64, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  74. A. Di Martino, M. Sittinger, and M. V. Risbud, “Chitosan: a versatile biopolymer for orthopaedic tissue-engineering,” Biomaterials, vol. 26, no. 30, pp. 5983–5990, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  75. G. Lisignoli, S. Cristino, A. Piacentini et al., “Cellular and molecular events during chondrogenesis of human mesenchymal stromal cells grown in a three-dimensional hyaluronan based scaffold,” Biomaterials, vol. 26, no. 28, pp. 5677–5686, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  76. S. H. Park, S. R. Park, S. I. Chung, K. S. Pai, and B. H. Min, “Tissue-engineered cartilage using fibrin/hyaluronan composite gel and its in vivo implantation,” Artificial Organs, vol. 29, no. 10, pp. 838–845, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  77. E. Malicev, D. Radosavljevic, and N. K. Velikonja, “Fibrin gel improved the spatial uniformity and phenotype of human chondrocytes seeded on collagen scaffolds,” Biotechnology and Bioengineering, vol. 96, no. 2, pp. 364–370, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  78. C. K. Kuo, W. J. Li, R. L. Mauck, and R. S. Tuan, “Cartilage tissue engineering: its potential and uses,” Current Opinion in Rheumatology, vol. 18, no. 1, pp. 64–73, 2006. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus
  79. D. Nesic, R. Whiteside, M. Brittberg, D. Wendt, I. Martin, and P. Mainil-Varlet, “Cartilage tissue engineering for degenerative joint disease,” Advanced Drug Delivery Reviews, vol. 58, no. 2, pp. 300–322, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  80. M. W. Kessler and D. A. Grande, “Tissue engineering and cartilage,” Organogenesis, vol. 4, no. 1, pp. 28–32, 2008. View at Google Scholar · View at Scopus
  81. L. Li, J. H. P. Hui, J. C. H. Goh, F. Chen, and E. H. Lee, “Chitin as a scaffold for mesenchymal stem cells transfers in the treatment of partial growth arrest,” Journal of Pediatric Orthopaedics, vol. 24, no. 2, pp. 205–210, 2004. View at Google Scholar · View at Scopus
  82. G. C. B. Medrado, C. B. Machado, P. Valerio, M. D. Sanches, and A. M. Goes, “The effect of a chitosan-gelatin matrix and dexamethasone on the behavior of rabbit mesenchymal stem cells,” Biomedical Materials, vol. 1, no. 3, pp. 155–161, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  83. K. Uematsu, K. Hattori, Y. Ishimoto et al., “Cartilage regeneration using mesenchymal stem cells and a three-dimensional poly-lactic-glycolic acid (PLGA) scaffold,” Biomaterials, vol. 26, no. 20, pp. 4273–4279, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  84. G. Chen, T. Sato, T. Ushida, N. Ochiai, and T. Tateishi, “Tissue engineering of cartilage using a hybrid scaffold of synthetic polymer and collagen,” Tissue Engineering, vol. 10, no. 3-4, pp. 323–330, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  85. A. Haisch, S. Klaring, A. Groger, C. Gebert, and M. Sittinger, “A tissue-engineering model for the manufacture of auricular-shaped cartilage implants,” European Archives of Oto-Rhino-Laryngology, vol. 259, no. 6, pp. 316–321, 2002. View at Google Scholar
  86. T. L. Spain, C. M. Agrawal, and K. A. Athanasiou, “New technique to extend the useful life of a biodegradable cartilage implant,” Tissue Engineering, vol. 4, no. 4, pp. 343–352, 1998. View at Google Scholar · View at Scopus
  87. K. H. Park and K. Yun, “Immobilization of Arg-Gly-Asp (RGD) sequence in a thermosensitive hydrogel for cell delivery using pheochromocytoma cells (PC12),” Journal of Bioscience and Bioengineering, vol. 97, no. 6, pp. 374–377, 2004. View at Google Scholar · View at Scopus
  88. J. H. Cho, S. H. Kim, K. D. Park et al., “Chondrogenic differentiation of human mesenchymal stem cells using a thermosensitive poly(N-isopropylacrylamide) and water-soluble chitosan copolymer,” Biomaterials, vol. 25, pp. 5743–5751, 2004. View at Google Scholar
  89. A. F. Steinert, U. Noth, and R. S. Tuan, “Concepts in gene therapy for cartilage repair,” Injury, vol. 39, supplement 1, pp. 97–113, 2008. View at Publisher · View at Google Scholar · View at PubMed
  90. F. D. Shuler, H. I. Georgescu, C. Niyibizi et al., “Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta1 gene into articular chondrocytes,” Journal of Orthopaedic Research, vol. 18, no. 4, pp. 585–592, 2000. View at Google Scholar
  91. P. Smith, F. D. Shuler, H. I. Georgescu et al., “Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1,” Arthritis and Rheumatism, vol. 43, no. 5, pp. 1156–1164, 2000. View at Publisher · View at Google Scholar
  92. C. Hidaka, M. Quitoriano, R. F. Warren, and R. G. Crystal, “Enhanced matrix synthesis and in vitro formation of cartilage-like tissue by genetically modified chondrocytes expressing BMP-7,” Journal of Orthopaedic Research, vol. 19, no. 5, pp. 751–758, 2001. View at Publisher · View at Google Scholar · View at PubMed
  93. A. J. Nixon, B. D. Brower-Toland, S. J. Bent et al., “Insulinlike growth factor-I gene therapy applications for cartilage repair,” Clinical Orthopaedics and Related Research, supplement 379, pp. S201–S213, 2000. View at Google Scholar
  94. S. R. Tew, Y. Li, P. Pothancharoen, L. M. Tweats, R. E. Hawkins, and T. E. Hardingham, “Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes,” Osteoarthritis and Cartilage, vol. 13, no. 1, pp. 80–89, 2005. View at Publisher · View at Google Scholar · View at PubMed
  95. S. B. Trippel, S. C. Ghivizzani, and A. J. Nixon, “Gene-based approaches for the repair of articular cartilage,” Gene Therapy, vol. 11, no. 4, pp. 351–359, 2004. View at Publisher · View at Google Scholar · View at PubMed
  96. C. Hu, Y. Wu, Y. Wan, Q. Wang, and J. Song, “Introduction of hIGF-1 gene into bone marrow stromal cells and its effects on the cell's biological behaviors,” Cell Transplantation, vol. 17, no. 9, pp. 1067–1081, 2008. View at Publisher · View at Google Scholar
  97. H. Song, K. Kwon, S. Lim et al., “Transfection of mesenchymal stem cells with the FGF-2 gene improves their survival under hypoxic conditions,” Molecules and Cells, vol. 19, no. 3, pp. 402–407, 2005. View at Publisher · View at Google Scholar
  98. X. H. Liu, C. G. Bai, Z. Y. Xu et al., “Therapeutic potential of angiogenin modified mesenchymal stem cells: angiogenin improves mesenchymal stem cells survival under hypoxia and enhances vasculogenesis in myocardial infarction,” Microvascular Research, vol. 76, no. 1, pp. 23–30, 2008. View at Publisher · View at Google Scholar · View at PubMed
  99. G. D. Palmer, A. Steinert, A. Pascher et al., “Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro,” Molecular Therapy, vol. 12, no. 2, pp. 219–228, 2005. View at Publisher · View at Google Scholar · View at PubMed
  100. C. H. Evans, J. N. Gouze, E. Gouze, P. D. Robbins, and S. C. Ghivizzani, “Osteoarthritis gene therapy,” Gene Therapy, vol. 11, no. 4, pp. 379–389, 2004. View at Publisher · View at Google Scholar · View at PubMed
  101. R. C. Mccarty, S. Gronthos, A. C. Zannettino, B. K. Foster, and C. J. Xian, “Characterisation and developmental potential of ovine bone marrow derived mesenchymal stem cells,” Journal of Cellular Physiology, vol. 219, no. 2, pp. 324–333, 2009. View at Publisher · View at Google Scholar · View at PubMed
  102. C. H. Evans, G. D. Palmer, A. Pascher et al., “Facilitated endogenous repair: making tissue engineering simple, practical, and economical,” Tissue Engineering, vol. 13, no. 8, pp. 1987–1993, 2007. View at Publisher · View at Google Scholar · View at PubMed
  103. G. Chamberlain, J. Fox, B. Ashton, and J. Middleton, “Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing,” Stem Cells, vol. 25, no. 11, pp. 2739–2749, 2007. View at Publisher · View at Google Scholar · View at PubMed
  104. E. B. Hunziker and L. C. Rosenberg, “Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membrane,” Journal of Bone and Joint Surgery. American, vol. 78, no. 5, pp. 721–733, 1996. View at Google Scholar
  105. J. A. Buckwalter and A. J. Grodzinsky, “Loading of healing bone, fibrous tissue, and muscle: implications for orthopaedic practice,” The Journal of the American Academy of Orthopaedic Surgeons, vol. 7, no. 5, pp. 291–299, 1999. View at Google Scholar
  106. C. J. Xian, F. H. Zhou, R. C. McCarty, and B. K. Foster, “Intramembranous ossification mechanism for bone bridge formation at the growth plate cartilage injury site,” Journal of Orthopaedic Research, vol. 22, no. 2, pp. 417–426, 2004. View at Publisher · View at Google Scholar · View at PubMed
  107. G. Arasapam, M. Scherer, J. C. Cool, B. K. Foster, and C. J. Xian, “Roles of COX-2 and iNOS in the bony repair of the injured growth plate cartilage,” Journal of Cellular Biochemistry, vol. 99, no. 2, pp. 450–461, 2006. View at Publisher · View at Google Scholar · View at PubMed
  108. R. Chung, J. C. Cool, M. A. Scherer, B. K. Foster, and C. J. Xian, “Roles of neutrophil-mediated inflammatory response in the bony repair of injured growth plate cartilage in young rats,” Journal of Leukocyte Biology, vol. 80, no. 6, pp. 1272–1280, 2006. View at Publisher · View at Google Scholar · View at PubMed
  109. F. H. Zhou, B. K. Foster, X. F. Zhou, A. J. Cowin, and C. J. Xian, “TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats,” Journal of Bone and Mineral Research, vol. 21, no. 7, pp. 1075–1088, 2006. View at Publisher · View at Google Scholar · View at PubMed
  110. R. Chung, B. K. Foster, and C. J. Xian, “Injury responses and repair mechanisms of the injured growth plate,” Frontiers in Bioscience (Scholar Edition), vol. 3, pp. 117–125, 2011. View at Google Scholar
  111. J. D. Kisiday, S. Morisset, A. Grodzinsky, and D. Frisbie, “In vitro migration of equine mesenchymal stem cells in response to selec growth factors,” in Proceedings of the 51st Annual Meeting of the Orthopaedic Research Society, p. 0352, Washington, DC, USA, February 2005.
  112. A. Dar, P. Goichberg, V. Shinder et al., “Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells,” Nature Immunology, vol. 6, no. 10, pp. 1038–1046, 2005. View at Publisher · View at Google Scholar · View at PubMed
  113. T. Kitaori, H. Ito, E. M. Schwarz et al., “Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model,” Arthritis and Rheumatism, vol. 60, no. 3, pp. 813–823, 2009. View at Publisher · View at Google Scholar · View at PubMed
  114. S. Schenk, N. Mal, A. Finan et al., “Monocyte chemotactic protein-3 is a myocardial mesenchymal stem cell homing factor,” Stem Cells, vol. 25, pp. 245–251, 2007. View at Google Scholar
  115. A. Ode, G. N. Duda, J. D. Glaeser et al., “Toward biomimetic materials in bone regeneration: functional behavior of mesenchymal stem cells on a broad spectrum of extracellular matrix components,” Journal of Biomedical Materials Research. Part A, vol. 95, no. 4, pp. 1114–1124, 2010. View at Publisher · View at Google Scholar · View at PubMed