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Stem Cells International
Volume 2011, Article ID 607569, 6 pages
http://dx.doi.org/10.4061/2011/607569
Review Article

Immune Reactions following Cord Blood Transplantations in Adults

Advanced Molecular Epidemiology Research Institute, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan

Received 15 January 2011; Revised 21 March 2011; Accepted 19 April 2011

Academic Editor: Yoshihisa Morishita

Copyright © 2011 Hiroto Narimatsu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Miyakoshi, K. Yuji, M. Kami et al., “Successful engraftment after reduced-intensity umbilical cord blood transplantation for adult patients with advanced hematological diseases,” Clinical Cancer Research, vol. 10, no. 11, pp. 3586–3592, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. J. N. Barker, D. J. Weisdorf, T. E. DeFor, B. R. Blazar, J. S. Miller, and J. E. Wagner, “Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning,” Blood, vol. 102, no. 5, pp. 1915–1919, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. G. F. Sanz, S. Saavedra, D. Flanelles et al., “Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies,” Blood, vol. 98, no. 8, pp. 2332–2338, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. T. F. Goggins and D. A. Rizzieri, “Nonmyeloablative allogeneic stem cell transplantation using alternative donors,” Cancer Control, vol. 11, no. 2, pp. 86–96, 2004. View at Google Scholar · View at Scopus
  5. V. Rocha, M. Labopin, G. Sanz et al., “Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia,” New England Journal of Medicine, vol. 351, no. 22, pp. 2276–2285, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. M. J. Laughlin, M. Eapen, P. Rubinstein et al., “Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia,” New England Journal of Medicine, vol. 351, no. 22, pp. 2265–2275, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. L. P. Koh and N. J. Chao, “Umbilical cord blood transplantation in adults using myeloablative and nonmyeloablative preparative regimens,” Biology of Blood and Marrow Transplantation, vol. 10, no. 1, pp. 1–22, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. H. Schoemans, K. Theunissen, J. Maertens, M. Boogaerts, C. Verfaillie, and J. Wagner, “Adult umbilical cord blood transplantation: a comprehensive review,” Bone Marrow Transplantation, vol. 38, no. 2, pp. 83–93, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. G. D. Long, M. Laughlin, B. Madan et al., “Unrelated umbilical cord blood transplantation in adult patients,” Biology of Blood and Marrow Transplantation, vol. 9, no. 12, pp. 772–780, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. P. Rubinstein, C. Carrier, A. Scaradavou et al., “Outcomes among 562 recipients of placental-blood transplants from unrelated donors,” New England Journal of Medicine, vol. 339, no. 22, pp. 1565–1577, 1998. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. E. Gluckman, V. Rocha, A. Boyer-Chammard et al., “Outcome of cord-blood transplantation from related and unrelated donors,” New England Journal of Medicine, vol. 337, no. 6, pp. 373–381, 1997. View at Publisher · View at Google Scholar · View at PubMed
  12. F. Locatelli, V. Rocha, C. Chastang et al., “Factors associated with outcome after cord blood transplantation in children with acute leukemia,” Blood, vol. 93, no. 11, pp. 3662–3671, 1999. View at Google Scholar
  13. V. Rocha, J. E. Wagner Jr., K. A. Sobocinski et al., “Graft-versus-host disease in children who have received a cord blood or bone marrow transplant from an HLA-identical sibling,” New England Journal of Medicine, vol. 342, no. 25, pp. 1846–1854, 2000. View at Publisher · View at Google Scholar · View at PubMed
  14. S. Takahashi, T. Iseki, J. Ooi et al., “Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies,” Blood, vol. 104, no. 12, pp. 3813–3820, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. S. Takahashi, J. Ooi, A. Tomonari et al., “Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen,” Blood, vol. 109, no. 3, pp. 1322–1330, 2007. View at Publisher · View at Google Scholar · View at PubMed
  16. J. E. Wagner, J. N. Barker, T. E. DeFor et al., “Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival,” Blood, vol. 100, no. 5, pp. 1611–1618, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. G. Michel, V. Rocha, S. Chevret et al., “Unrelated cord blood transplantation for childhood acute myeloid leukemia: a Eurocord Group analysis,” Blood, vol. 102, no. 13, pp. 4290–4297, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. B. G. Thomson, K. A. Robertson, D. Gowan et al., “Analysis of engraftment, graft-versus-host disease, and immune recovery following unrelated donor cord blood transplantation,” Blood, vol. 96, no. 8, pp. 2703–2711, 2000. View at Google Scholar · View at Scopus
  19. H. Narimatsu, S. Miyakoshi, T. Yamaguchi et al., “Chronic graft-versus-host disease following umbilical cord blood transplantation: retrospective survey involving 1072 patients in Japan,” Blood, vol. 112, no. 6, pp. 2579–2582, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. K. Sugimoto, H. Narimatsu, T. Kawase et al., “Clinical characteristics of chronic graft-versus-host disease following umbilical cord blood transplantation for adults,” Bone Marrow Transplantation, vol. 41, no. 8, pp. 729–736, 2008. View at Publisher · View at Google Scholar · View at PubMed
  21. Y. Kishi, M. Kami, S. Miyakoshi et al., “Early immune reaction after reduced-intensity cord-blood transplantation for adult patients,” Transplantation, vol. 80, no. 1, pp. 34–40, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Miyakoshi, M. Kami, T. Tanimoto et al., “Tacrolimus as prophylaxis for acute graft-versus-host disease in reduced intensity cord blood transplantation for adult patients with advanced hematologic diseases,” Transplantation, vol. 84, no. 3, pp. 316–322, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. H. Narimatsu, S. Terakura, K. Matsuo et al., “Short-term methotrexate could reduce early immune reactions and improve outcomes in umbilical cord blood transplantation for adults,” Bone Marrow Transplantation, vol. 39, no. 1, pp. 31–39, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. K. J. Patel, R. D. Rice, R. Hawke et al., “Pre-engraftment syndrome after double-unit cord blood transplantation: a distinct syndrome not associated with acute graft-versus-host disease,” Biology of Blood and Marrow Transplantation, vol. 16, no. 3, pp. 435–440, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. H. Frangoul, L. Wang, F. E. Harrell, R. Ho, and J. Domm, “Preengraftment syndrome after unrelated cord blood transplant is a strong predictor of acute and chronic graft-versus-host disease,” Biology of Blood and Marrow Transplantation, vol. 15, no. 11, pp. 1485–1488, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. S. Miyakoshi, M. Kami, Y. Kishi et al., “Fatal hepatic failure associated with graft rejection following reduced-intensity stem-cell transplantation for chronic idiopathic myelofibrosis (CIMF),” Leukemia and Lymphoma, vol. 45, no. 12, pp. 2513–2516, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. B. K. Cho, V. P. Rao, Q. Ge, H. N. Eisen, and J. Chen, “Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells,” Journal of Experimental Medicine, vol. 192, no. 4, pp. 549–556, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. P. Rubinstein and C. E. Stevens, “Placental blood for bone marrow replacement: the New York Blood Center's program and clinical results,” Best Practice and Research: Clinical Haematology, vol. 13, no. 4, pp. 565–584, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. J. N. Barker, S. M. Davies, T. DeFor, N. K. C. Ramsay, D. J. Weisdorf, and J. E. Wagner, “Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis,” Blood, vol. 97, no. 10, pp. 2957–2961, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. J. E. Wagner, J. Rosenthal, R. Sweetman et al., “Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft- versus-host disease,” Blood, vol. 88, no. 3, pp. 795–802, 1996. View at Google Scholar · View at Scopus
  31. M. L. MacMillan, D. J. Weisdorf, C. G. Brunstein et al., “Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors,” Blood, vol. 113, no. 11, pp. 2410–2415, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. M. R. Verneris, C. G. Brunstein, J. Barker et al., “Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units,” Blood, vol. 114, no. 19, pp. 4293–4299, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. C. G. Brunstein, J. E. Wagner, D. J. Weisdorf et al., “Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity,” Blood, vol. 113, no. 22, pp. 5628–5634, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. O. Ringdén, “Bone marrow transplantation using unrelated donors for haematological malignancies,” Medical Oncology, vol. 14, no. 1, pp. 11–22, 1997. View at Google Scholar · View at Scopus
  35. N. Uchida, A. Wake, S. Takagi et al., “Umbilical cord blood transplantation after reduced-intensity conditioning for elderly patients with hematologic diseases,” Biology of Blood and Marrow Transplantation, vol. 14, no. 5, pp. 583–590, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. H. Narimatsu, M. Watanabe, A. Kohno et al., “High incidence of graft failure in unrelated cord blood transplantation using a reduced-intensity preparative regimen consisting of fludarabine and melphalan,” Bone Marrow Transplantation, vol. 41, no. 8, pp. 753–756, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. S. Takagi, Y. Ota, N. Uchida et al., “Successful engraftment after reduced-intensity umbilical cord blood transplantation for myelofibrosis,” Blood, vol. 116, no. 4, pp. 649–652, 2010. View at Publisher · View at Google Scholar · View at PubMed
  38. C. Julian-Reynier, I. Nippert, J. M. Calefato et al., “Genetics in clinical practice: general practitioners' educational priorities in European countries,” Genetics in Medicine, vol. 10, no. 2, pp. 107–113, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  39. M. Arora, S. Nagaraj, J. E. Wagner et al., “Chronic Graft-Versus-Host Disease (cGVHD) following unrelated donor Hematopoietic Stem Cell Transplantation (HSCT): higher response rate in recipients of Unrelated Donor (URD) Umbilical Cord Blood (UCB),” Biology of Blood and Marrow Transplantation, vol. 13, no. 10, pp. 1145–1152, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. J. Ooi, T. Iseki, S. Takahashi et al., “Unrelated cord blood transplantation for adult patients with de novo acute myeloid leukemia,” Blood, vol. 103, no. 2, pp. 489–491, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  41. J. Ooi, T. Iseki, S. Takahashi et al., “Unrelated cord blood transplantation for adult patients with advanced myelodysplastic syndrome,” Blood, vol. 101, no. 12, pp. 4711–4713, 2003. View at Google Scholar · View at Scopus
  42. Y. Morishima, T. Sasazuki, H. Inoko et al., “The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors,” Blood, vol. 99, no. 11, pp. 4200–4206, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. Y. Atsuta, R. Suzuki, K. Yamamoto et al., “Risk and prognostic factors for Japanese patients with chronic graft-versus-host disease after bone marrow transplantation,” Bone Marrow Transplantation, vol. 37, no. 3, pp. 289–296, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  44. M. Eapen, V. Rocha, G. Sanz et al., “Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis,” The Lancet Oncology, vol. 11, no. 7, pp. 653–660, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. D. S. Subramaniam, D. H. Fowler, and S. Z. Pavletic, “Chronic graft-versus-host disease in the era of reduced-intensity conditioning,” Leukemia, vol. 21, no. 5, pp. 853–859, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  46. B. J. Chen, X. Cui, G. D. Sempowski et al., “A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution,” Blood, vol. 99, no. 1, pp. 364–371, 2002. View at Publisher · View at Google Scholar · View at Scopus
  47. S. J. Lee, J. P. Klein, A. J. Barrett et al., “Severity of chronic graft-versus-host disease: association with treatment-related mortality and relapse,” Blood, vol. 100, no. 2, pp. 406–414, 2002. View at Publisher · View at Google Scholar · View at Scopus
  48. K. M. Sullivan, E. Agura, C. Anasetti et al., “Chronic graft-versus-host disease and other late complications of bone marrow transplantation,” Seminars in Hematology, vol. 28, no. 3, pp. 250–259, 1991. View at Google Scholar · View at Scopus
  49. M. M. Horowitz, R. P. Gale, P. M. Sondel et al., “Graft-versus-leukemia reactions after bone marrow transplantation,” Blood, vol. 75, no. 3, pp. 555–562, 1990. View at Google Scholar · View at Scopus
  50. B. Oran, J. E. Wagner, T. E. Defor, D. J. Weisdorf, and C. G. Brunstein, “Effect of conditioning regimen intensity on acute myeloid leukemia outcomes after umbilical cord blood transplantation,” Biology of Blood and Marrow Transplantation, 2011. View at Publisher · View at Google Scholar · View at PubMed
  51. A. H. Filipovich, D. Weisdorf, S. Pavletic et al., “National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report,” Biology of Blood and Marrow Transplantation, vol. 11, no. 12, pp. 945–956, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus