Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2011 (2011), Article ID 610514, 8 pages
http://dx.doi.org/10.4061/2011/610514
Review Article

Risk Factors and Options to Improve Engraftment in Unrelated Cord Blood Transplantation

1Université de Paris 7, Hospital Saint-Louis, 1, Avenue Claude Vellefaux, 75010 Paris, France
2Sirio Libanes e ITACI Hospital (Children's Cancer Hospital), University of Sao Paulo, Sao Paulo, Brazil

Received 4 January 2011; Accepted 9 February 2011

Academic Editor: Pilar Solves

Copyright © 2011 Anna D. Petropoulou and Vanderson Rocha. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. Rocha and F. Locatelli, “Searching for alternative hematopoietic stem cell donors for pediatric patients,” Bone Marrow Transplantation, vol. 41, no. 2, pp. 207–214, 2008. View at Publisher · View at Google Scholar · View at PubMed
  2. V. Rocha, J. E. Wagner Jr., K. A. Sobocinski et al., “Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and International Bone Marrow Transplant Registry Working Committee on Alternative Donor and Stem Cell Sources,” New England Journal of Medicine, vol. 342, no. 25, pp. 1846–1854, 2000. View at Google Scholar
  3. V. Rocha, J. Cornish, E. L. Sievers et al., “Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukaemia,” Blood, vol. 97, no. 10, pp. 2962–2971, 2001. View at Google Scholar
  4. V. Rocha, M. Labopin, G. Sanz et al., “Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia,” New England Journal of Medicine, vol. 351, no. 22, pp. 2276–2285, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. M. Laughlin, M. Eapen, P. Rubinstein et al., “Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukaemia,” New England Journal of Medicine, vol. 351, no. 22, pp. 2265–2275, 2004. View at Google Scholar
  6. M. Eapen, P. Rubinstein, M. J. Zhang et al., “Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study,” Lancet, vol. 369, no. 9577, pp. 1947–1954, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. T. Niehues, V. Rocha, A. H. Filipovich et al., “Factors affecting lymphocyte subset reconstitution after either related or unrelated cord blood transplantation in children—a Eurocord analysis,” British Journal of Haematology, vol. 114, no. 1, pp. 42–48, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. K. V. Komanduri, L. S. St John, M. De Lima et al., “Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing,” Blood, vol. 110, no. 13, pp. 4543–4551, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. F. Frassoni, F. Gualandi, M. Podestà et al., “Direct intrabone transplant of unrelated cord-blood cells in acute leukaemia: a phase I/II study,” The Lancet Oncology, vol. 9, no. 9, pp. 831–839, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. C. Delaney, B. Varnum-Finney, K. Aoyama, C. Brashem-Stein, and I. D. Bernstein, “Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells,” Blood, vol. 106, no. 8, pp. 2693–2699, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. M. de Lima, J. McMannis, A. Gee et al., “Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial,” Bone Marrow Transplantation, vol. 41, no. 9, pp. 771–778, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. J. N. Barker, D. J. Weisdorf, T. E. DeFor et al., “Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy,” Blood, vol. 105, no. 3, pp. 1343–1347, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. C. G. Brunstein, J. N. Barker, D. J. Weisdorf et al., “Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease,” Blood, vol. 110, no. 8, pp. 3064–3070, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. J. N. Barker, D. J. Weisdorf, T. E. DeFor, B. R. Blazar, J. S. Miller, and J. E. Wagner, “Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning,” Blood, vol. 102, no. 5, pp. 1915–1919, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. K. K. Ballen, T. R. Spitzer, B. Y. Yeap et al., “Double unrelated reduced-intensity umbilical cord blood transplantation in adults,” Biology of Blood and Marrow Transplantation, vol. 13, no. 1, pp. 82–89, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. J. Fernandes, V. Rocha, M. Robin et al., “Second transplant with two unrelated cord blood units for early graft failure after haematopoietic stem cell transplantation,” British Journal of Haematology, vol. 137, no. 3, pp. 248–251, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. G. Bautista, J. R. Cabrera, C. Regidor et al., “Cord blood transplants supported by co-infusion of mobilized hematopoietic stem cells from a third-party donor,” Bone Marrow Transplantation, vol. 43, no. 5, pp. 365–373, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. M. L. MacMillan, B. R. Blazar, T. E. DeFor, and J. E. Wagner, “Transplantation of ex-vivo culture-expanded parental haploidentical mesenchymal stem cells to promote engraftment in pediatric recipients of unrelated donor umbilical cord blood: results of a phase I-II clinical trial,” Bone Marrow Transplantation, vol. 43, no. 6, pp. 447–454, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. E. Gluckman, V. Rocha, A. Boyer-Chammard et al., “Outcome of cord-blood transplantation from related and unrelated donors,” New England Journal of Medicine, vol. 337, no. 6, pp. 373–381, 1997. View at Publisher · View at Google Scholar · View at PubMed
  20. P. Rubinstein, C. Carrier, A. Scaradavou et al., “Outcomes among 562 recipients of placental-blood transplants from unrelated donors,” New England Journal of Medicine, vol. 339, no. 22, pp. 1565–1577, 1998. View at Publisher · View at Google Scholar · View at PubMed
  21. J. E. Wagner, J. N. Barker, T. E. DeFor et al., “Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival,” Blood, vol. 100, no. 5, pp. 1611–1618, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. G. F. Sanz, S. Saavedra, D. Planelles et al., “Standardized, unrelated donor cord blood transplantation in adults with hematological malignancies,” Blood, vol. 98, no. 8, pp. 2332–2338, 2001. View at Google Scholar
  23. E. Gluckman, V. Rocha, W. Arcese et al., “Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice,” Experimental Hematology, vol. 32, no. 4, pp. 397–407, 2004. View at Google Scholar
  24. W. Arcese, V. Rocha, M. Labopin et al., “Unrelated cord blood transplants in adults with hematologic malignancies,” Haematologica, vol. 91, no. 2, pp. 223–230, 2006. View at Google Scholar
  25. J. Kurtzberg, V. K. Prasad, S. L. Carter et al., “Results of the cord blood transplantation study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies,” Blood, vol. 112, no. 10, pp. 4318–4327, 2008. View at Google Scholar
  26. S. Nabhan, V. Rocha, W. Arcese et al., “Influence of myeloablative conditioning regimens on outcomes after single unrelated cord blood transplantation for adults with leukemia: an analysis on behalf of eurocord-EBMT-netcord-blood,” Blood, vol. 112, 2008, abstract no. 155. View at Google Scholar
  27. F. Locatelli, V. Rocha, W. Reed et al., “Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease,” Blood, vol. 101, no. 6, pp. 2137–2143, 2003. View at Publisher · View at Google Scholar · View at PubMed
  28. G. Sanz and E. Gluckman, “Umbilical cord blood transplantation,” Current Opinion in Hematology, vol. 11, no. 6, pp. 375–385, 2004. View at Google Scholar
  29. E. Gluckman, V. Rocha, I. Ionescu et al., “Results of unrelated cord blood transplant in fanconi anemia patients: risk factor analysis for engraftment and survival,” Biology of Blood and Marrow Transplantation, vol. 13, no. 9, pp. 1073–1082, 2007. View at Publisher · View at Google Scholar · View at PubMed
  30. Y. Atsuta, R. Suzuki, T. Nagamura-Inoue et al., “Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukaemia,” Blood, vol. 113, no. 8, pp. 1631–1638, 2009. View at Google Scholar
  31. S. Takahashi, T. Iseki, J. Ooi et al., “Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies,” Blood, vol. 104, no. 12, pp. 3813–3820, 2004. View at Publisher · View at Google Scholar · View at PubMed
  32. J. N. Barker, A. Scaradavou, and C. E. Stevens, “Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies,” Blood, vol. 115, no. 9, pp. 1843–1849, 2010. View at Publisher · View at Google Scholar · View at PubMed
  33. A. Ruggeri, R. Peffault De Latour, V. Rocha et al., “Double cord blood transplantation in patients with high risk bone marrow failure syndromes,” British Journal of Haematology, vol. 143, no. 3, pp. 404–408, 2008. View at Publisher · View at Google Scholar · View at PubMed
  34. M. R. Verneris, C. G. Brunstein, J. Barker et al., “Relapse risk after umbilical cord blood transplantation: enhanced graft versus leukemia effect in recipients of two units,” Blood, vol. 114, no. 19, pp. 4293–4299, 2009. View at Google Scholar
  35. C. Rodriguesi, G. Sanz, C. Brunstein et al., “Analysis of risk factors for outcomes after unrelated cord blood transplantation in adults with lymphoid malignancies: a study by the eurocord-Netcord and lymphoma working party of the European group for blood and marrow transplantation,” Journal of Clinical Oncology, vol. 27, no. 2, pp. 256–263, 2009. View at Publisher · View at Google Scholar · View at PubMed
  36. C. Brunstein, J. Gutman, D. Weisdorf et al., “Allogeneic hematopoietic cell transplantation for hematological malignancy: relative risks and benefits of double umbilical cord blood,” Blood, vol. 116, no. 22, pp. 4693–4699, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. B. Rio, S. Furst, M. Renaud et al., “Encouraging results of unrelated cord blood transplantation (UCBT) after homogenous reduced intensity conditioning (RIC) in adults with hematological malignancy: impact of HLA disparities on outcomes. A French multicentre study on behalf of the SFGM-TC and eurocord,” Bone Marrow Transplantation, vol. 43, p. S10, 2009. View at Google Scholar
  38. M. N. Fernández, C. Regidor, and R. Cabrera, “Unrelated umbilical cord blood transplants in adults: early recovery of neutrophils by supportive co-transplantation of a low number of highly purified peripheral blood CD34+ cells from an HLA-haploidentical donor,” Experimental Hematology, vol. 31, no. 6, pp. 535–544, 2003. View at Google Scholar
  39. M. N. Fernandez, “Improving the outcome of cord blood transplantation: use of mobilized HSC and other cells from third party donors,” British Journal of Haematology, vol. 147, no. 2, pp. 161–176, 2009. View at Google Scholar
  40. R. Gonzalo-Daganzo, C. Regidor, T. Martín-Donaire et al., “Results of a pilot study on the use of third-party donor mesenchymal stromal cells in cord blood transplantation in adults,” Cytotherapy, vol. 11, no. 3, pp. 278–288, 2009. View at Google Scholar
  41. H. E. Broxmeyer, S. Cooper, D. M. Hass, J. K. Hathaway, F. B. Stehman, G. Hangoc et al., “Experimental basis of cord blood transplantation,” Bone Marrow Transplantation, vol. 44, no. 10, pp. 627–633, 2009. View at Publisher · View at Google Scholar · View at PubMed
  42. K. W. Christopherson, G. Hangoc, C. R. Mantel, and H. E. Broxmeyer, “Modulation of hematopoietic stem cell homing and engraftment by CD26,” Science, vol. 305, no. 5686, pp. 1000–1003, 2004. View at Publisher · View at Google Scholar · View at PubMed
  43. T. B. Campbell, G. Hangoc, Y. Liu, K. Pollok, and H. E. Broxmeyer, “Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice,” Stem Cells Developmen, vol. 3, pp. 347–354, 2007. View at Publisher · View at Google Scholar · View at PubMed
  44. M. H. Dallas, B. Varnum-Finney, P. J. Martin, and I. D. Bernstein, “Enhanced t-cell reconstitution by hematopoietic progenitors expanded ex vivo using the notch ligand delta,” Blood, vol. 109, no. 8, pp. 3579–3587, 2007. View at Publisher · View at Google Scholar · View at PubMed
  45. C. Delaney, S. Heimfeld, C. Brashem-Stein, H. Voorhies, R. L. Manger, and I. D. Bernstein, “Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution,” Nature Medicine, vol. 16, no. 2, pp. 232–236, 2010. View at Publisher · View at Google Scholar · View at PubMed
  46. S. Castello, M. Podesta, V. G. Menditto et al., “Intra-bone marrow injection of bone marrow and cord blood cells: an alternative way of transplantation associated with a higher seeding efficiency,” Experimental Hematology, vol. 32, no. 8, pp. 782–787, 2004. View at Google Scholar