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Stem Cells International
Volume 2012, Article ID 168385, 9 pages
http://dx.doi.org/10.1155/2012/168385
Review Article

Stem Cells and Gene Therapy for Cartilage Repair

1Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo 200, Trigoria, 00128 Rome, Italy
2Centro Integrato di Ricerca (CIR), Università Campus Bio-Medico, Via Alvaro del Portillo, 21, 00128, Rome, Italy
3Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, London E1 4DG, UK

Received 15 October 2011; Accepted 6 December 2011

Academic Editor: Wasim S. Khan

Copyright © 2012 Umile Giuseppe Longo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [35 citations]

The following is the list of published articles that have cited the current article.

  • M.O. Brix, and C. Chiari, “Cartilage repair,” Zeitschrift fur Orthopadie und Unfallchirurgie, vol. 150, no. 4, pp. e121–e142, 2012. View at Publisher · View at Google Scholar
  • Sonia Martínez-Herrero, Ignacio M. Larráyoz, Laura Ochoa-Callejero, Josune García-Sanmartín, and Alfredo Martínez, “Adrenomedullin as a Growth and Cell Fate Regulatory Factor for Adult Neural Stem Cells,” Stem Cells International, vol. 2012, pp. 1–18, 2012. View at Publisher · View at Google Scholar
  • Giacomo Rizzello, Umile Giuseppe Longo, Stefano Petrillo, Alfredo Lamberti, Wasim Sardar Khan, Nicola Maffulli, and Vincenzo Denaro, “Growth factors and stem cells for the management of anterior cruciate ligament tears.,” The open orthopaedics journal, vol. 6, pp. 525–30, 2012. View at Publisher · View at Google Scholar
  • Yu Wen, Shi-xiang Fan, Xian-hong Yi, Bin Li, and Jun Pan, “Biological characteristics and chondrogenic differentiation of bone marrow-derived multipotent adult progenitor cells,” Chinese Journal of Tissue Engineering Research, vol. 16, no. 27, pp. 4968–4973, 2012. View at Publisher · View at Google Scholar
  • Xiang-Hui Huang, Ming Ling, Shi-Zhang Liu, Yan-Hai Chang, Xiang-Hui Dong, and Xin Tian, “Effect of recombinant adeno-associated virus transforming growth factor-beta 1 on the infection activity of bone marrow mesenchymal stem cells,” Chinese Journal of Tissue Engineering Research, vol. 16, no. 36, pp. 6679–6684, 2012. View at Publisher · View at Google Scholar
  • Yao Wu, Wen Jiang, Kui Luo, Hongmei Song, Zhongwei Gu, Li Li, and Fang Lan, “Superparamagnetic Iron Oxide Nanoparticles as MRI contrast agents for Non-invasive Stem Cell Labeling and Tracking,” Theranostics, vol. 3, no. 8, pp. 595–615, 2013. View at Publisher · View at Google Scholar
  • Taku Saito, Daisuke Mori, Shinsuke Ohba, Makoto Otsu, Ung-il Chung, Fumiko Yano, Koji Eto, Hiroshi Kawaguchi, Hironori Hojo, Hiromitsu Nakauchi, and Sakae Tanaka, “Generation of Col2a1-EGFP iPS Cells for Monitoring Chondrogenic Differentiation,” Plos One, vol. 8, no. 9, 2013. View at Publisher · View at Google Scholar
  • Lauren Polstein, and Charles Gersbach, “Spatiotemporal Genetic Control of Cellular Systems,” Tissue and Organ Regeneration, pp. 157–197, 2014. View at Publisher · View at Google Scholar
  • Junyi Liao, Ning Hu, Nian Zhou, Liangbo Lin, Chen Zhao, Shixiong Yi, Tingxu Fan, Wei Bao, Xi Liang, Hong Chen, Wei Xu, Cheng Chen, Qiang Cheng, Yongming Zeng, Weike Si, Zhong Yang, and Wei Huang, “Sox9 Potentiates BMP2-Induced Chondrogenic Differentiation and Inhibits BMP2-Induced Osteogenic Differentiation,” Plos One, vol. 9, no. 2, 2014. View at Publisher · View at Google Scholar
  • F. Launay, “Sports-related overuse injuries in children,” Orthopaedics & Traumatology: Surgery & Research, 2014. View at Publisher · View at Google Scholar
  • Peng Guo, Zhong-li Shi, An Liu, Tiao Lin, Fanggang Bi, Mingmin Shi, and Shi-gui Yan, “Effects of Cartilage Oligomeric Matrix Protein on Bone Morphogenetic Protein-2-induced Differentiation of Mesenchymal Stem Cells,” Orthopaedic Surgery, vol. 6, no. 4, pp. 280–287, 2014. View at Publisher · View at Google Scholar
  • M. Mazor, E. Lespessailles, R. Coursier, R. Daniellou, T. M. Best, and H. Toumi, “Mesenchymal stem-cell potential in cartilage repair: an update,” Journal of Cellular and Molecular Medicine, 2014. View at Publisher · View at Google Scholar
  • Eduardo Branco de Sousa, Priscila Ladeira Casado, Vivaldo Moura Neto, Maria Eugenia Leite Duarte, and Diego Pinheiro Aguiar, “Synovial fluid and synovial membrane mesenchymal stem cells: latest discoveries and therapeutic perspectives,” Stem Cell Research & Therapy, vol. 5, 2014. View at Publisher · View at Google Scholar
  • Barron, Nandakumar, van Blitterswijk, Habibovic, Moroni, Shannon, Murphy, Barry, Merghani, Shaw, Coleman, Hayes, Ansboro, Manian, O’Malley, and Connolly, “Evaluation of Cartilage Repair by Mesenchymal Stem Cells Seeded on a PEOT/PBT Scaffold in an Osteochondral Defect,” Annals of Biomedical Engineering, vol. 43, no. 9, pp. 2069–2082, 2015. View at Publisher · View at Google Scholar
  • Sajjad Ashraf, Byung-Hyun Cha, Jin-Su Kim, Jongchan Ahn, Inbo Han, Hansoo Park, and Soo-Hong Lee, “Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration,” Osteoarthritis and Cartilage, 2015. View at Publisher · View at Google Scholar
  • Shun-Cheng Wu, Hsu-Feng Hsiao, Mei-Ling Ho, Yung-Li Hung, Je-Ken Chang, Gwo-Jaw Wang, and Chau-Zen Wang, “Suppression of discoidin domain receptor 1 expression enhances the chondrogenesis of adipose-derived stem cells,” American Journal Of Physiology-Cell Physiology, vol. 308, no. 9, pp. C685–C696, 2015. View at Publisher · View at Google Scholar
  • Nian Zhou, Wei Bao, Xi Liang, Xu Wei, Hong Chen, Cheng Chen, Qiang Chen, Xin Lin, Wei Huang, Ning Hu, Jun-Yi Liao, Liang-Bo Lin, Chen Zhao, Wei-Ke Si, Zhong Yang, Shi-Xiong Yi, and Ting-Xu Fan, “HIF-1α as a regulator of BMP2-induced chondrogenic differentiation, osteogenic differentiation, and endochondral ossification in stem cells,” Cellular Physiology and Biochemistry, vol. 36, no. 1, pp. 44–60, 2015. View at Publisher · View at Google Scholar
  • Kuei-Chang Li, and Yu-Chen Hu, “Cartilage Tissue Engineering: Recent Advances and Perspectives from Gene Regulation/Therapy,” Advanced Healthcare Materials, 2015. View at Publisher · View at Google Scholar
  • Aline Ambrogi Franco Prado, Phelipe Oliveira Favaron, Luis Claudio Lopes Correia da Silva, Raquel Yvonne Arantes Baccarin, Maria Angelica Miglino, and Durvanei Augusto Maria, “Characterization of mesenchymal stem cells derived from the equine synovial fluid and membrane,” Bmc Veterinary Research, vol. 11, 2015. View at Publisher · View at Google Scholar
  • Teresa Fernández-Muiños, Lourdes Recha-Sancho, Patricia Lopez-Chicon, Cristina Castells-Sala, Alvaro Mata, and Carlos E. Semino, “Bimolecular based heparin and self-assembling hydrogel for tissue engineering applications,” Acta Biomaterialia, 2015. View at Publisher · View at Google Scholar
  • Niina Hopper, John Wardale, Daniel Howard, Roger Brooks, Neil Rushton, and Frances Henson, “Peripheral Blood Derived Mononuclear Cells Enhance the Migration and Chondrogenic Differentiation of Multipotent Mesenchymal Stromal Cells,” Stem Cells International, vol. 2015, pp. 1–9, 2015. View at Publisher · View at Google Scholar
  • Taku Saito, Fumiko Yano, Daisuke Mori, Manabu Kawata, Kazuto Hoshi, Tsuyoshi Takato, Hideki Masaki, Makoto Otsu, Koji Eto, Hiromitsu Nakauchi, Ung-il Chung, and Sakae Tanaka, “Hyaline cartilage formation and tumorigenesis of implanted tissues derived from human induced pluripotent stem cells ,” Biomedical Research, vol. 36, no. 3, pp. 179–186, 2015. View at Publisher · View at Google Scholar
  • Valerie Barron, Martin Neary, Khalid Merghani Salid Mohamed, Sharon Ansboro, Georgina Shaw, Grace O'Malley, Niall Rooney, Frank Barry, and Mary Murphy, “Evaluation of the Early In Vivo Response of a Functionally Graded Macroporous Scaffold in an Osteochondral Defect in a Rabbit Model,” Annals Of Biomedical Engineering, vol. 44, no. 5, pp. 1832–1844, 2016. View at Publisher · View at Google Scholar
  • Kolja Them, J Salamon, P Szwargulski, S Sequeira, M G Kaul, C Lange, H Ittrich, and Tobias Knopp, “Increasing the sensitivity for stem cell monitoring in system-function based magnetic particle imaging,” Physics in Medicine and Biology, vol. 61, no. 9, pp. 3279–3290, 2016. View at Publisher · View at Google Scholar
  • H. Thomas Temple, and Theodore I. Malinin, “Orthobiologics in the Foot and Ankle,” Foot and Ankle Clinics, vol. 21, no. 4, pp. 809–823, 2016. View at Publisher · View at Google Scholar
  • Nevres Hürriyet Aydoğan, Talip Kara, Alper Öztürk, Kadir Bahadır Alemdaroğlu, Deniz Gül, Serkan İltar, and Ahmet Özmeriç, “The clinical effect of platelet–rich plasma prepared through different activation methods on patients with knee osteoarthritis,” Journal of Clinical and Analytical Medicine, vol. 7, no. 6, pp. 767–771, 2016. View at Publisher · View at Google Scholar
  • Nian Zhou, Hong Chen, Qi Li, Xin Lin, Ning Hu, Chen Zhao, Wei Xu, Wei Huang, Jun-Yi Liao, Liang-Bo Lin, Zhen-Ming Hu, and Xi Liang, “BMP2 induces chondrogenic differentiation, osteogenic differentiation and endochondral ossification in stem cells,” Cell and Tissue Research, vol. 366, no. 1, pp. 101–111, 2016. View at Publisher · View at Google Scholar
  • S.G. Davies, P.D. Kennewell, A.J. Russell, L. Silpa, R. Westwood, and G.M. Wynne, “Regenerative Medicine,” Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, 2016. View at Publisher · View at Google Scholar
  • Ippokratis Pountos, and Peter V. Giannoudis, “Modulation of cartilage's response to injury: Can chondrocyte apoptosis be reversed?,” Injury, vol. 48, no. 12, pp. 2657–2669, 2017. View at Publisher · View at Google Scholar
  • Federico Giuseppe Usuelli, Nicola Maffulli, Camilla Maccario, Riccardo D'Ambrosi, Cristian Indino, and Luigi Manzi, “Adipose-derived stem cells in orthopaedic pathologies,” British Medical Bulletin, vol. 124, no. 1, pp. 31–54, 2017. View at Publisher · View at Google Scholar
  • Mahasen Al-Najar, Hiba Khalil, Jihad Al-Ajlouni, Eman Al-Antary, Mohammad Hamdan, Reem Rahmeh, Dana Alhattab, Osama Samara, Mohamad Yasin, Amenah Al Abdullah, Esraa Al-jabbari, Dima Hmaid, Hanan Jafar, and Abdalla Awidi, “Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study,” Journal of Orthopaedic Surgery and Research, vol. 12, no. 1, 2017. View at Publisher · View at Google Scholar
  • Lizeth Fuentes-Mera, Alberto Camacho, Nidia K. Moncada-Saucedo, and Víctor Peña-Martínez, “Current Applications of Mesenchymal Stem Cells for Cartilage Tissue Engineering,” Mesenchymal Stem Cells - Isolation, Characterization and Applications, 2017. View at Publisher · View at Google Scholar
  • Hechmi Toumi, Eric Lespessailles, and Marija Mazor, “Stem Cell-Based Therapies for Osteoarthritis: From Pre-Clinical to Clinical Applications,” Mesenchymal Stem Cells - Isolation, Characterization and Applications, 2017. View at Publisher · View at Google Scholar
  • Rokhsareh Rohban, and Thomas Rudolf Pieber, “Mesenchymal Stem and Progenitor Cells in Regeneration: Tissue Specificity and Regenerative Potential,” Stem Cells International, vol. 2017, pp. 1–16, 2017. View at Publisher · View at Google Scholar
  • Erman Chen, Ling Yang, Chenyi Ye, Wei Zhang, Jisheng Ran, Deting Xue, Zhengke Wang, Zhijun Pan, and Qiaoling Hu, “An asymmetric chitosan scaffold for tendon tissue engineering: in vitro and in vivo evaluation with rat tendon stem/progenitor cells,” Acta Biomaterialia, 2018. View at Publisher · View at Google Scholar