Review Article
Engaging Stem Cells for Customized Tendon Regeneration
Table 2
(a) Dermal scaffolds for tendon and ligament augmentation. (b) Synthetic scaffolds for tendon and ligament augmentation.
(a) |
| Scaffold | Composition | Status | Support for growth factor release? |
| Matrix xenografts | | | | Restore | Porcine SIS | FDA approved | Yes (TGF-β, VEGF, FGF-2) | CuffPatch | Porcine SIS | FDA approved | Yes (EGF, TGF-β, FGF) | TissueMend | Bovine dermal extracellular matrix | FDA approved | No | Zimmer collagen repair patch | Porcine acellular dermal matrix | FDA approved | No | Permacol | Porcine acellular dermal matrix | FDA approved | No | Conexa | Porcine acellular dermal matrix | Experimental | No |
| Matrix allografts | | | | GraftJacket | Human acellular dermal matrix | FDA approved | Yes |
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(b) |
| Scaffold | Status | Support for growth factor release? |
| Non degradable synthetic polymers | | | Polyethylene terephthalate (Stryker-Dacron) | FDA approved | No | Polypropylene (Kennedy Ligament Augmentation Device) | FDA approved | Yes | Poly(tetrafluoro ethylene) (GoreTex) | FDA approved | Yes |
| Biodegradable Synthetic Polymers | | | Polylactic acid | FDA approved | Yes | Polyglycolic acid | FDA approved | Yes | Poly(lactide-co-glycolic acid) | FDA approved | Yes | Polydioxanone | FDA approved | No | Polycaprolactone | FDA approved | Yes | Hydrothane/PET | FDA approved | | x-Repair Device (poly-L-lactide) | FDA approved | Yes | Hyaluronan-based non woven mesh (HYAFF11) | Experimental | Yes | Electrochemically aligned collagen matrices (ELAC) | Experimental | No | Poly(1,8-octanediol-co-citrate) | Experimental | Yes |
| Nanofiber matrices | | | Peptide Amphiphiles | Experimental | Yes |
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