Secreted Factors from Bone Marrow Stromal Cells Upregulate IL-10 and Reverse Acute Kidney Injury

<table>BMSC-CM significantly upregulates IL-10 in AKI rats, and BMSC-CM is not an exogenous source of IL-10<i>.</i> (a) Rat serum IL-10 was measured via ELISA from rats administered a lethal dose of cisplatin (7.5 mg/kg) and then treated with either vehicle or BMSC-CM at 3, 9, 24, 48, and 72 hours after cisplatin administration. Blood was collected via tail snip, and the serum was analyzed on day 3. <svg height="13.95" id="M35" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>-test. (b) IL-10 was measured via ELISA in whole BMSC-CM.</table>

Stem Cells International

fig6

Figure 6

Figure 6: Secreted Factors from Bone Marrow Stromal Cells Upregulate IL-10 and Reverse Acute Kidney Injury 