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Stem Cells International
Volume 2012, Article ID 452102, 8 pages
http://dx.doi.org/10.1155/2012/452102
Clinical Study

Heart Cells with Regenerative Potential from Pediatric Patients with End Stage Heart Failure: A Translatable Method to Enrich and Propagate

1The Congenital Heart Institute of Florida (CHIF), Saint Petersburg and Tampa, FL, USA
2Seattle Children’s Hospital Research Institute, University of Washington, 1900 Ninth Ave North, Seattle, WA 98101, USA
3The Congenital Heart Institute of Florida (CHIF), All Children’s Hospital, University of South Florida College of Medicine, Cardiac Surgical Associates of Florida (CSAoF), Saint Petersburg and Tampa, FL, USA
4Department of Pathology and Laboratory Medicine, All Children’s Hospital, Saint Petersburg, FL, USA
5The Congenital Heart Institute of Florida (CHIF), All Children’s Hospital, University of South Florida College of Medicine, Pediatric Cardiology Associates/Pediatrix, Saint Petersburg and Tampa, FL, USA
6Nova Southeastern University, Ft. Lauderdale, FL, USA

Received 19 April 2012; Revised 22 June 2012; Accepted 29 June 2012

Academic Editor: J. Gimble

Copyright © 2012 Ann Steele et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. C. H. Hsieh, V. F. M. Segers, M. E. Davis et al., “Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury,” Nature Medicine, vol. 13, no. 8, pp. 970–974, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. L. Barile, E. Messina, A. Giacomello, and E. Marbán, “Endogenous cardiac stem cells,” Progress in Cardiovascular Diseases, vol. 50, no. 1, pp. 31–48, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. D. T. Hsu and G. D. Pearson, “Heart failure in children part I: history, etiology, and pathophysiology,” Circulation, vol. 2, no. 1, pp. 63–70, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. J. P. Jacobs, F. G. Lacour-Gayet, M. L. Jacobs et al., “Initial application in the STS congenital database of complexity adjustment to evaluate surgical case mix and results,” Annals of Thoracic Surgery, vol. 79, no. 5, pp. 1635–1649, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. D. E. Creighton, C. M. T. Robertson, R. S. Sauve et al., “Neurocognitive, functional, and health outcomes at 5 years of age for children after complex cardiac surgery at 6 weeks of age or younger,” Pediatrics, vol. 120, no. 3, pp. e478–e486, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Piran, G. Veldtman, S. Siu, G. D. Webb, and P. P. Liu, “Heart failure and ventricular dysfunction in patients with single or systemic right ventricles,” Circulation, vol. 105, no. 10, pp. 1189–1194, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. M. M. Boucek, P. Aurora, L. B. Edwards et al., “Registry of the international society for heart and lung transplantation: tenth official pediatric heart transplantation report—2007,” Journal of Heart and Lung Transplantation, vol. 26, no. 8, pp. 796–807, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Kirk, L. B. Edwards, A. Y. Kucheryavaya et al., “The registry of the international society for heart and lung transplantation: thirteenth official pediatric heart transplantation report—2010,” Journal of Heart and Lung Transplantation, vol. 29, no. 10, pp. 1119–1128, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. J. P. Jacobs, A. Asante-Korang, S. M. O'Brien et al., “Lessons learned from 119 consecutive cardiac transplants for pediatric and congenital heart disease,” Annals of Thoracic Surgery, vol. 91, no. 4, pp. 1248–1254, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. R. J. Boucek Jr. and M. R. Chrisant, “Cardiac transplantation for hypoplastic left heart syndrome,” Cardiology in the Young, vol. 14, pp. 83–87, 2004. View at Google Scholar · View at Scopus
  11. S. Z. Paige, C. E. Murry, and R. J. Boucek Jr., “Potential strategies for myocardial regeneration in pediatric patients,” Pediatric Health, vol. 2, no. 4, pp. 503–516, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Urbanek, D. Torella, F. Sheikh et al., “Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 24, pp. 8692–8697, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. M. A. Laflamme, S. Zbinden, S. E. Epstein, and C. E. Murry, “Cell-based therapy for myocardial ischemia and infarction: pathophysiological mechanisms,” Annual Review of Pathology, vol. 2, pp. 307–339, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Rupp, J. Bauer, T. Tonn et al., “Intracoronary administration of autologous bone marrow-derived progenitor cells in a critically ill two-yr-old child with dilated cardiomyopathy,” Pediatric Transplantation, vol. 13, no. 5, pp. 620–623, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Rupp, A. M. Zeiher, S. Dimmeler et al., “A regenerative strategy for heart failure in hypoplastic left heart syndrome: intracoronary administration of autologous bone marrow-derived progenitor cells,” Journal of Heart and Lung Transplantation, vol. 29, no. 5, pp. 574–577, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. V. K. Shah and K. K. Shalia, “Stem cell therapy in acute myocardial infarction: a pot of gold or Pandora's box,” Stem Cells International, Article ID 536758, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Bearzi, M. Rota, T. Hosoda et al., “Human cardiac stem cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 35, pp. 14068–14073, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Mishra, K. Vijayan, E. J. Colletti et al., “Characterization and functionality of cardiac progenitor cells in congenital heart patients,” Circulation, vol. 123, no. 4, pp. 364–373, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. M. A. Laflamme and C. E. Murry, “Heart regeneration,” Nature, vol. 473, no. 7347, pp. 326–335, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. M. J. Goumans, T. P. de Boer, A. M. Smits et al., “TGF-β1 induces efficient differentiation of human cardiomyocyte progenitor cells into functional cardiomyocytes in vitro,” Stem Cell Research, vol. 1, no. 2, pp. 138–149, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Steele, O. Y. Jones, F. Gok et al., “Stem-like cells traffic from heart ex vivo, expand in vitro, and can be transplanted in vivo,” Journal of Heart and Lung Transplantation, vol. 24, no. 11, pp. 1930–1939, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Bolli, A. R. Chugh, D. D'Amario, J. H. Loughran, M. F. Stoddard, S. Ikram et al., “Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial,” The Lancet, vol. 378, no. 9806, pp. 1847–1857, 2011. View at Google Scholar
  23. R. R. Smith, L. Barile, H. C. Cho et al., “Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens,” Circulation, vol. 115, no. 7, pp. 896–908, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Messina, L. De Angelis, G. Frati et al., “Isolation and expansion of adult cardiac stem cells from human and murine heart,” Circulation Research, vol. 95, no. 9, pp. 911–921, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Hyde-Dunn and G. E. Jones, “Visualization of cell replication using antibody to proliferating cell nuclear antigen,” Methods in Molecular Biology, vol. 75, pp. 341–347, 1997. View at Google Scholar · View at Scopus
  26. S. Miyamoto, N. Kawaguchi, G. M. Ellison, R. Matsuoka, T. Shin'Oka, and H. Kurosawa, “Characterization of long-term cultured c-kit+ cardiac stem cells derived from adult rat hearts,” Stem Cells and Development, vol. 19, no. 1, pp. 105–116, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. D. S. Sheridan, V. Surampudi, and R. R. Rao, “Analysis of embryoid bodies derived from human induced pluripotent stem cells as a means to assess pluripotency,” Stem Cells International, vol. 2012, Article ID 738910, 9 pages, 2012. View at Publisher · View at Google Scholar
  28. D. Srivastava, “Making or breaking the heart: from lineage determination to morphogenesis,” Cell, vol. 126, no. 6, pp. 1037–1048, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. S. D. Bird, P. A. Doevendans, M. A. Van Rooijen et al., “The human adult cardiomyocyte phenotype,” Cardiovascular Research, vol. 58, no. 2, pp. 423–434, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Sato, I. Shiraishi, T. Takamatsu, and K. Hamaoka, “Detection of TUNEL-positive cardiomyocytes and C-kit-positive progenitor cells in children with congenital heart disease,” Journal of Molecular and Cellular Cardiology, vol. 43, no. 3, pp. 254–261, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Urbanek, D. Cesselli, M. Rota et al., “Stem cell niches in the adult mouse heart,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 24, pp. 9226–9231, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Sandstedt, M. Jonsson, A. Lindahl, A. Jeppsson, and J. Asp, “C-kit+ CD45- Cells found in the adult human heart represent a population of endothelial progenitor cells,” Basic Research in Cardiology, vol. 105, no. 4, pp. 545–556, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Zhou, P. Pan, L. Yao et al., “CD117-positive cells of the heart: progenitor cells or mast cells?” Journal of Histochemistry and Cytochemistry, vol. 58, no. 4, pp. 309–316, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. D. Angert, R. M. Berretta, H. Kubo et al., “Repair of the injured adult heart involves new myocytes potentially derived from resident cardiac stem cells,” Circulation Research, vol. 108, no. 10, pp. 1226–1237, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. D. R. Davis, E. Kizana, J. Terrovitis et al., “Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies,” Journal of Molecular and Cellular Cardiology, vol. 49, no. 2, pp. 312–321, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. J. Steele, A. Steele, P. Steele, W. Schleif, J. Jacobs, W. Chamizo et al., “Cardiac tissue explant culturing: a novel method to study human pediatric injury-related cytokine signaling,” Circulation, vol. 120, article S611, 2009. View at Google Scholar
  37. A. V. Schittini, P. F. Celedon, M. A. Stimamiglio et al., “Human cardiac explant-conditioned medium: soluble factors and cardiomyogenic effect on mesenchymal stem cells,” Experimental Biology and Medicine, vol. 235, no. 8, pp. 1015–1024, 2010. View at Publisher · View at Google Scholar · View at Scopus