Research Article
In Vivo Healing of Meniscal Lacerations Using Bone Marrow-Derived Mesenchymal Stem Cells and Fibrin Glue
Table 2
Group 0 is fibrin only treatment; Group 1 is fibrin with BMSCs treatment. See Table
1 for grading score rubric.
| Category/Score | Group | 0 | 1 | 2 | 3 | value | Gross observations | | | | | | |
| Adherent vessels | Group 0 | 4 (33.3%) | 3 (25%) | 5(41.7%) | | 0.0094 | Group 1 | 0 (0%) | 10 (83.3%) | 2 (16.7%) | | | | | | | | | | Tissue adhesion | Group 0 | 5 (41.7%) | 7 (58.3%) | | | 1.00 | Group 1 | 5 (41.7%) | 7 (58.3%) | | | | | | | | | | | Bond | Group 0 | | 2 (16.7%) | 10 (83.3%) | | 0.640 | Group 1 | | 4 (33.3%) | 8(66.7%) | | |
| H&E section observations | | | | | | |
| Cellular in-growth | Group 0 | 3(25.0%) | 6 (50.0%) | 3(25.0%) | | 1.000 | Group 1 | 3(25.0%) | 5 (41.7%) | 4 (33.3%) | | | | | | | | | | Predominant cell type | Group 0 | | 8 (66.7%) | 1(8.3%) | 3(25.0%) | 0.822 | Group 1 | | 6(50.0%) | 1(8.3%) | 5(41.7%) | | | | | | | | | Fiber organization | Group 0 | 3(25.0%) | 7(58.3%) | 2(16.7%) | | 1.000 | Group 1 | 2(16.7%) | 7 (58.3%) | 3(25.0%) | | | | | | | | | | Fibrinous tissue between sections | Group 0 | 7(58.3%) | 5(41.7%) | | | 0.214 | Group 1 | 3(25.0%) | 9(75.0%) | | | | | | | | | | | Total bond distance | Group 0 | 0 | 3(25.0%) | 4(33.3%) | 5(41.7%) | 0.569 | Group 1 | 0 | 1(8.35) | 7(58.3%) | 4(33.3%) | |
| SOFG section observations | | | | | | |
| SOFG % positive staining | Group 0 | 5(41.7%) | 3(25.0%) | 4(33.3%) | 0 | 0.428 | Group 1 | 5(41.7%) | 5(41.7%) | 1(8.3%) | 1(8.3%) | | | | | | | | | Thickness of repair tissue | Group 0 | | 5(41.7%) | 6(50.0%) | 1(8.3%) | 0.680 | Group 1 | | 8(66.7%) | 3(25.0%) | 1(8.3%) | | | | | | | | | Cell repopulation | Group 0 | 5(41.7%) | 6(50.0%) | 1(8.3%) | | 0.520 | Group 1 | 7(58.3%) | 3(25.0%) | 2(16.7%) | | |
|
|