Review Article

Nonhuman Primate Induced Pluripotent Stem Cells in Regenerative Medicine

Table 1

Publications on nonhuman primate iPS cells.

SpeciesTitle of publicationcDNAs used for reprogrammingOrigin of cDNAs

Rhesus macaque (Macaca mulatta)Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts [24]POU5F1, SOX2 KLF4 and MYC Rhesus
Common marmoset (Callithrix jacchus)Generation of induced pluripotent stem cells from newborn marmoset skin fibroblasts [25]POU5F1, SOX2 KLF4 and MYC Human
Common marmoset (Callithrix jacchus)Generating induced pluripotent stem cells from common marmoset (Callithrix jacchus) fetal liver cells using defined factors, including Lin28 [26]POU5F1, SOX2, KLF4, MYC, NANOG and LIN28 Human
Rhesus macaque (Macaca mulatta)Reprogramming Huntington monkey skin cells into pluripotent stem cells [27]POU5F1, SOX2 and KLF4 Rhesus
Pigtailed macaque (Macaca nemestrina)Efficient generation of nonhuman primate induced pluripotent stem cells [28]POU5F1, SOX2 KLF4 and MYC Human
Cynomolgus monkey (Macaca fascicularis)Development of histocompatible primate induced pluripotent stem cells for neural transplantation [29]POU5F1, SOX2 KLF4 and MYC Human
Rhesus macaque (Macaca mulatta)Generation of pancreatic insulin-producing cells from rhesus monkey induced pluripotent stem cells [30]POU5F1, SOX2 KLF4 and MYC Rhesus
Pigtailed macaque (Macaca nemestrina)Safeguarding nonhuman primate iPS cells with suicide genes [31]POU5F1, SOX2 KLF4 and MYC Human
Drill (Mandrillus leucophaeus)Induced pluripotent stem cells from highly endangered species [32]POU5F1, SOX2 KLF4 and MYC Human
Cynomolgus monkey (Macaca fascicularis)Induction of retinal pigment epithelial cells from monkey iPS cells [33]POU5F1, SOX2 KLF4 and MYC Human

The table lists the publications (in order of publication, up to September 2011) that have reported the derivation and characterization of nonhuman primate iPS cells. All used mixtures of retroviruses, carrying the indicated cDNAs.