Review Article

Adrenomedullin as a Growth and Cell Fate Regulatory Factor for Adult Neural Stem Cells

Figure 3

Schematic cartoon of the potential mechanisms of action of AM in NSC. AM increases the proliferation of neural multipotent progenitor cells probably through the activation of the transcription factor HIF-1. In addition, AM regulates the differentiation rate of progenitor cells into neurons, astrocytes, or oligodendrocytes. Some of these actions may be mediated by the interaction of AM and PAMP with the cytoskeleton.
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