Regulation of Injury-Induced Neurogenesis by Nitric Oxide

Table 1

Regulation of adult neurogenesis by inflammatory mediators.

Inflammatory factor	Proliferation of NSC	Differentiation of NCS	Survival of NSC	References
IL-1	↑ or ↓	—	↓	[51]
IL-6	↓	↓ neuronal	↓	[4, 46, 52]
IFN-gamma	↓	↑ neuronal	↓	[42, 53–56]
	↑	—	=	[57, 58]
TNF-alpha	—	↓ neuronal	↓	[40]
	—	—	↓	[43, 54]
	↑	↓ neuronal (TNF-R1)	=	[59]
	↑	↑ neuronal (TNF-R2)	↑	[60]
	↑	↑ neuronal (TNF-R1)	↑	[61]
		↑ astrocytic
	↑ or ↓	↑ neuronal (TNF-R2)	↑ or ↓	[36, 44]
		↓ neuronal (TNF-R1)
SDF-1alpha	↑ or ↓	↑ neuronal	↑	[62, 63]

The effects listed here may not be direct. ↑: increase; ↓: decrease; =: no change; —: no report.