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Stem Cells International
Volume 2012 (2012), Article ID 980353, 9 pages
Review Article

Mesenchymal Stem Cells as a Potent Cell Source for Bone Regeneration

Department of Stem Cell and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, ACECR, 1665659911 Tehran, Iran

Received 24 August 2011; Revised 21 November 2011; Accepted 5 December 2011

Academic Editor: Jan Kramer

Copyright © 2012 Elham Zomorodian and Mohamadreza Baghaban Eslaminejad. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


While small bone defects heal spontaneously, large bone defects need surgical intervention for bone transplantation. Autologous bone grafts are the best and safest strategy for bone repair. An alternative method is to use allogenic bone graft. Both methods have limitations, particularly when bone defects are of a critical size. In these cases, bone constructs created by tissue engineering technologies are of utmost importance. Cells are one main component in the manufacture of bone construct. A few cell types, including embryonic stem cells (ESCs), adult osteoblast, and adult stem cells, can be used for this purpose. Mesenchymal stem cells (MSCs), as adult stem cells, possess characteristics that make them good candidate for bone repair. This paper discusses different aspects of MSCs that render them an appropriate cell type for clinical use to promote bone regeneration.