DNA Methylation Changes during In Vitro Propagation of Human Mesenchymal Stem Cells: Implications for Their Genomic Stability?

Figure 2

Epigenetic changes (in particular DNA methylation) at specific gene promoters during long-term culture of hMSCs may regulate processes like senescence and proliferation but also genomic stability. Many statistically significant pathways involved in methylation variations between early and late passages of Figure 1 concern cell cycle regulation, DNA repair, and cancer (light-blue circles).