Optimal Labeling Dose, Labeling Time, and Magnetic Resonance Imaging Detection Limits of Ultrasmall Superparamagnetic Iron-Oxide Nanoparticle Labeled Mesenchymal Stromal Cells
MRI images of porcine myocardium before and after USPIO labeled MSC injection. T2*-images of porcine myocardium before injection (a1–a5) and after injection (b1–b5) of USPIO-labeled MSCs. USPIO labeled MSCs are identified as hypointense areas (arrows). MSCs: mesenchymal stromal cells. USPIO: ultrasmall superparamagnetic iron-oxide.