Optimal Labeling Dose, Labeling Time, and Magnetic Resonance Imaging Detection Limits of Ultrasmall Superparamagnetic Iron-Oxide Nanoparticle Labeled Mesenchymal Stromal Cells

Table 1

Number of MRI phantoms.

Number of MSCs	USPIO dose	USPIO incubation time
		2 hours	6 hours	21 hours
2.5×10^5	full	13	10	13
5×10^5	full	11	7	9
1×10^6	full	12	7	8
2.5×10^5	half	14	5	9
5×10^5	half	11	5	8
1×10^6	half	11	4	8
2.5×10^5	0	14	5	12
5×10^5	0	10	6	11
1×10^6	0	12	5	8

MSC: mesenchymal stromal cell; USPIO: ultrasmall super-paramagnetic iron-oxide. USPIO dose—full = 10 𝜇g per 10⁵ cells; half = 5 𝜇g per 10⁵ cells.