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Growth factors secreted by CD133+/CD34+ BMMNCs | |
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(a) Proangiogenic factors | |
Angiogenin | |
Angiopoitien-2 | |
b-FGF (basic fibroblast growth factor) | |
PLGF (placenta growth factor) | |
VEGF-121 (vascular endothelial growth factor-121) | |
VEGF165 (vascular endothelial growth factor-165) | |
VEGF-D (vascular endothelial growth factor-D) | |
|
(b) Proinflammatory factors | |
I-309 (CCL-1 (C-C motif) ligand-1) | |
MCP-1 (CCL-2 (C-C motif) ligand-2) | |
MIP-1a (CCL-4 (C-C motif) ligand-4) | |
RANTES (CCL-5 (C-C motif) ligand-5) | |
IL-1ra (interleukin-1 receptor antagonist) | |
CXCL-16 (C-X-C motif) ligand-16 | |
MIF (macrophage migration inhibitory factor) | |
sTNFR-1 (soluble tumor necrosis factor receptor-1) | |
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(c) MMPs-TIMPs | |
MMP-1 (matrix metalloproteinase-1) | |
MMP-3 (matrix metalloproteinase-3) | |
MMP-9 (matrix metalloproteinase-9) | |
MMP-13 (matrix metalloproteinase-13) | |
TIMP-1 (tissue inhibitor of metalloproteinases-1) | |
TIMP-2 (tissue inhibitor of metalloproteinases-2) | |
TIMP-4 (tissue inhibitor of metalloproteinases-4) | |
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(d) Neurophilic factors | |
AGRP (agouti-related protein) | |
BDNF (brain-derived neurotrophic factor) | |
CTNF (human ciliary neurotrophic factor) | |
b-NGF (basic nerve growth factor) | |
AREG (amphiregulin) | |
NT-3 (neurotrophin-3) | |
NT-4 (neurotrophin-4) | |
Activin A (promotes neural cell differentiation) | |
Prolactin (promotes neurogenesis in maternal and foetal brains) | |
|
(e) Morphogenetic proteins | |
BMP-4 (bone morphogenetic protein-4) | |
BMP-5 (bone morphogenetic protein-5) | |
BMP-6 (bone morphogenetic protein-6) | |
BMP-7 (bone morphogenetic protein-7) | |
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