Distinct iPS Cells Show Different Cardiac Differentiation Efficiency
Figure 6
Pharmacological studies of cardiomyocytes (CM) derived from mouse embryonic stem (ES) cells, Nanog induced pluripotent stem (iPS) cells, and Fbx15-iPS cells. ((a)–(c)) Multielectrode array (MEA) recordings in CM derived from ES (a), Nanog-iPS (b), and Fbx15-iPS cells (c) showing chronotropic responses to increasing doses of isoproterenol. (d) Summary of the positive chronotropic changes induced by isoproterenol. Data are the mean SEM. * and ** compared with 0 mM isoproterenol. ((e)–(g)) MEA recordings of negative chronotropic responses to increasing doses of verapamil in CM derived from ES (d), Nanog-iPS (e), and Fbx15-iPS cells (f). (h) Summary of the negative chronotropic changes induced by verapamil. Data are the mean SEM. * and ** compared with 0 mM verapamil.
