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Stem Cells International
Volume 2013, Article ID 892340, 10 pages
Review Article

The Necessity of a Systematic Approach for the Use of MSCs in the Clinical Setting

1Qatar Cardiovascular Research Center, Qatar Foundation, Qatar Science and Technology Park, Doha, Qatar
2Department of Genetic Medicine, Weill Cornell Medical College, Doha, Qatar
3Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, Qatar

Received 21 April 2013; Revised 26 May 2013; Accepted 5 June 2013

Academic Editor: Mohan Vemuri

Copyright © 2013 Christophe Michel Raynaud and Arash Rafii. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cell therapy has emerged as a potential therapeutic strategy in regenerative disease. Among different cell types, mesenchymal stem/stromal cells have been wildly studied in vitro, in vivo in animal models and even used in clinical trials. However, while clinical applications continue to increase markedly, the understanding of their physiological properties and interactions raises many questions and drives the necessity of more caution and supervised strategy in their use.