Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2014, Article ID 101349, 8 pages
http://dx.doi.org/10.1155/2014/101349
Research Article

DNA Methylation Is Involved in the Expression of miR-142-3p in Fibroblasts and Induced Pluripotent Stem Cells

1Division of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
2Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

Received 11 August 2014; Revised 4 November 2014; Accepted 14 November 2014; Published 2 December 2014

Academic Editor: Chia-Lin Wei

Copyright © 2014 Siti Razila Abdul Razak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Keller, “Embryonic stem cell differentiation: emergence of a new era in biology and medicine,” Genes & Development, vol. 19, no. 10, pp. 1129–1155, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. B. E. Bernstein, T. S. Mikkelsen, X. Xie et al., “A bivalent chromatin structure marks key developmental genes in embryonic stem cells,” Cell, vol. 125, no. 2, pp. 315–326, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. S. R. A. Razak, K. Ueno, N. Takayama et al., “Profiling of MicroRNA in human and mouse ES and iPS cells reveals overlapping but distinct MicroRNA expression patterns,” PLoS ONE, vol. 8, no. 9, Article ID e73532, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. C.-Z. Chen and H. F. Lodish, “MicroRNAs as regulators of mammalian hematopoiesis,” Seminars in Immunology, vol. 17, no. 2, pp. 155–165, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Sun, S. Varambally, C. A. Maher et al., “Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality,” Blood, vol. 117, no. 23, pp. 6172–6183, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. X. S. Wang, J. N. Gong, J. Yu et al., “MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia,” Blood, vol. 119, no. 21, pp. 4992–5004, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Nimmo, A. Ciau-Uitz, C. Ruiz-Herguido et al., “MiR-142-3p controls the specification of definitive hemangioblasts during ontogeny,” Developmental Cell, vol. 26, no. 3, pp. 237–249, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Skårn, T. Barøy, E. W. Stratford, and O. Myklebost, “Epigenetic regulation and functional characterization of microRNA-142 in mesenchymal cells,” PLoS ONE, vol. 8, no. 11, Article ID e79231, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Nishiyama, R. Kaneda, T. Ono et al., “miR-142-3p is essential for hematopoiesis and affects cardiac cell fate in zebrafish,” Biochemical and Biophysical Research Communications, vol. 425, no. 4, pp. 755–761, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. W. Hu, Y. Ye, W. Zhang, J. Wang, A. Chen, and F. Guo, “MiR-142-3p promotes osteoblast differentiation by modulating Wnt signaling,” Molecular Medicine Reports, vol. 7, no. 2, pp. 689–693, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. M. K. Lalwani, M. Sharma, A. R. Singh et al., “Reverse genetics screen in Zebrafish identifies a role of miR-142a-3p in vascular development and integrity,” PLoS ONE, vol. 7, no. 12, Article ID e52588, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. C. E. Gauwerky, K. Huebner, M. Isobe, P. C. Nowell, and C. M. Croce, “Activation of MYC in a masked t(8;17) translocation results in an aggressive B-cell leukemia,” Proceedings of the National Academy of Sciences of the United States of America, vol. 86, no. 22, pp. 8867–8871, 1989. View at Publisher · View at Google Scholar · View at Scopus
  13. W. Kwanhian, D. Lenza, J. Alles et al., “MicroRNA-142 is mutated in about 20% of diffuse large B-cell lymphoma,” Cancer Medicine, vol. 1, no. 2, pp. 141–155, 2012. View at Publisher · View at Google Scholar
  14. M. Lv, X. Zhang, H. Jia et al., “An oncogenic role of miR-142-3p in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor-α and cAMP/PKA pathways,” Leukemia, vol. 26, no. 4, pp. 769–777, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Wu, C. Cai, X. Wang, M. Liu, X. Li, and H. Tang, “MicroRNA-142-3p, a new regulator of RAC1, suppresses the migration and invasion of hepatocellular carcinoma cells,” FEBS Letters, vol. 585, no. 9, pp. 1322–1330, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Lee, M. Kim, J. Han et al., “MicroRNA genes are transcribed by RNA polymerase II,” The EMBO Journal, vol. 23, no. 20, pp. 4051–4060, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. W. Yuan, W. Sun, S. Yang et al., “Downregulation of microRNA-142 by proto-oncogene LMO2 and its co-factors,” Leukemia, vol. 22, no. 5, pp. 1067–1071, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Sun, J. Sun, T. Tomomi et al., “PU.1-dependent transcriptional regulation of miR-142 contributes to its hematopoietic cell-specific expression and modulation of IL-6,” Journal of Immunology, vol. 190, no. 8, pp. 4005–4013, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Takayama, S. Nishimura, S. Nakamura et al., “Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells,” Journal of Experimental Medicine, vol. 207, no. 13, pp. 2817–2830, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Kumaki, M. Oda, and M. Okano, “QUMA: quantification tool for methylation analysis,” Nucleic Acids Research, vol. 36, pp. W170–W175, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. P. H. Gunaratne, “Embryonic stem cell MicroRNAs: defining factors in induced pluripotent (iPS) and cancer (CSC) stem cells?” Current Stem Cell Research & Therapy, vol. 4, no. 3, pp. 168–177, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. B. G. Herrmann, S. Labeit, A. Poustka, T. R. King, and H. Lehrach, “Cloning of the T gene required in mesoderm formation in the mouse,” Nature, vol. 343, no. 6259, pp. 617–622, 1990. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Barreto, A. Schäfer, J. Marhold et al., “Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation,” Nature, vol. 445, no. 7128, pp. 671–675, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Escher, A. Hoang, S. Georges et al., “Demethylation using the epigenetic modifier, 5-azacytidine, increases the efficiency of transient transfection of macrophages,” Journal of Lipid Research, vol. 46, no. 2, pp. 356–365, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Han, P. D. Witmer, E. Casey, D. Valle, and S. Sukumar, “DNA methylation regulates microRNA expression,” Cancer Biology and Therapy, vol. 6, no. 8, pp. 1290–1294, 2007. View at Google Scholar · View at Scopus
  26. M.-R. Suh, Y. Lee, J. Y. Kim et al., “Human embryonic stem cells express a unique set of microRNAs,” Developmental Biology, vol. 270, no. 2, pp. 488–498, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Mazar, D. Khaitan, D. DeBlasio et al., “Epigenetic regulation of microRNA genes and the role of miR-34b in cell invasion and motility in human melanoma,” PLoS ONE, vol. 6, no. 9, Article ID e24922, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. J. M. Polo, E. Anderssen, R. M. Walsh et al., “A molecular roadmap of reprogramming somatic cells into iPS cells,” Cell, vol. 151, no. 7, pp. 1617–1632, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. T. S. Mikkelsen, J. Hanna, X. Zhang et al., “Dissecting direct reprogramming through integrative genomic analysis,” Nature, vol. 454, no. 7200, pp. 49–55, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. D. D. de Carvalho, J. S. You, and P. A. Jones, “DNA methylation and cellular reprogramming,” Trends in Cell Biology, vol. 20, no. 10, pp. 609–617, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Wang, J. Gu, J. A. Roth et al., “Pathway-based serum microRNA profiling and survival in patients with advanced stage non-small cell lung cancer,” Cancer Research, vol. 73, no. 15, pp. 4801–4809, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. Z. Lei, G. Xu, L. Wang et al., “MiR-142-3p represses TGF-β-induced growth inhibition through repression of TGFβR1 in non-small cell lung cancer,” The FASEB Journal, vol. 28, no. 6, pp. 2696–2704, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Watabe and K. Miyazono, “Roles of TGF-β family signaling in stem cell renewal and differentiation,” Cell Research, vol. 19, no. 1, pp. 103–115, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. G. Carraro, A. Shrestha, J. Rostkovius et al., “miR-142-3p balances proliferation and differentiation of mesenchymal cells during lung development,” Development, vol. 141, no. 6, pp. 1272–1281, 2014. View at Publisher · View at Google Scholar · View at Scopus