A Proposed Quantitative Index for Assessing the Potential Contribution of Reprogramming to Cancer Stem Cell Kinetics
Figure 1
The bottom and top transparent regions in (a) and (b) represent the percentages of CD133+ subpopulation in the U87-MG cell line before and after fractionated irradiation ( Gy), respectively [8]. (a) CSC fraction in silico after fractionated irradiation ( Gy) under different mechanisms (means ± SD, ). (b) The CD133+ fraction observed in the U87-MG population before and after fractionated irradiation can also be reproduced in silico by applying an induced reprogramming rate. In silico tumor regrowth dynamics for different rates of symmetric divisions and reprogramming: (c) total tumor cell number and (d) percentage of CSCs. Tumors initiated by a single surviving CSC maintain a steady proportion of CSCs under either (e) a constant symmetric division rate or (f) a constant cell reprogramming rate.
