Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2014 (2014), Article ID 768391, 12 pages
http://dx.doi.org/10.1155/2014/768391
Review Article

A Comparative View on Human Somatic Cell Sources for iPSC Generation

Institute of Neuroanatomy, Eberhard Karls University Tübingen, Österbergstraße 3, 72074 Tübingen, Germany

Received 18 July 2014; Revised 13 October 2014; Accepted 13 October 2014; Published 6 November 2014

Academic Editor: Gary E. Lyons

Copyright © 2014 Stefanie Raab et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Takahashi and S. Yamanaka, “Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors,” Cell, vol. 126, no. 4, pp. 663–676, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Maetzel, S. Sarkar, H. Wang et al., “Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick type C patient-specific iPS cells,” Stem Cell Reports, vol. 2, no. 6, pp. 866–880, 2014. View at Google Scholar
  3. R. Eggenschwiler, K. Loya, G. Wu et al., “Sustained knockdown of a disease-causing gene in patient-specific induced pluripotent stem cells using lentiviral vector-based gene therapy,” Stem Cells Translational Medicine, vol. 2, no. 9, pp. 641–654, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Reinhardt, B. Schmid, L. F. Burbulla et al., “Genetic correction of a lrrk2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression,” Cell Stem Cell, vol. 12, no. 3, pp. 354–367, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. L. U. W. Müller, G. Q. Daley, and D. A. Williams, “Upping the ante: recent advances in direct reprogramming,” Molecular Therapy, vol. 17, no. 6, pp. 947–953, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. V. Tabar and L. Studer, “Pluripotent stem cells in regenerative medicine: challenges and recent progress,” Nature Reviews Genetics, vol. 15, no. 2, pp. 82–92, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Takahashi, K. Tanabe, M. Ohnuki et al., “Induction of pluripotent stem cells from adult human fibroblasts by defined factors,” Cell, vol. 131, no. 5, pp. 861–872, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Novak, R. Shtrichman, I. Germanguz et al., “Enhanced reprogramming and cardiac differentiation of human keratinocytes derived from plucked hair follicles, using a single excisable lentivirus,” Cellular Reprogramming, vol. 12, no. 6, pp. 665–678, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Ban, N. Nishishita, N. Fusaki et al., “Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 34, pp. 14234–14239, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Okita, M. Nakagawa, H. Hyenjong, T. Ichisaka, and S. Yamanaka, “Generation of mouse induced pluripotent stem cells without viral vectors,” Science, vol. 322, no. 5903, pp. 949–953, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Warren, P. D. Manos, T. Ahfeldt et al., “Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA,” Cell Stem Cell, vol. 7, no. 5, pp. 618–630, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Huangfu, R. Maehr, W. Guo et al., “Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds,” Nature Biotechnology, vol. 26, no. 7, pp. 795–797, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Shi, C. Desponts, J. T. Do, H. S. Hahm, H. R. Schöler, and S. Ding, “Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds,” Cell Stem Cell, vol. 3, no. 5, pp. 568–574, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Liebau, P. U. Mahaddalkar, H. A. Kestler, A. Illing, T. Seufferlein, and A. Kleger, “A hierarchy in reprogramming capacity in different tissue microenvironments: what we know and what we need to know,” Stem Cells and Development, vol. 22, no. 5, pp. 695–706, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. Y.-H. Loh, S. Agarwal, I.-H. Park et al., “Generation of induced pluripotent stem cells from human blood,” Blood, vol. 113, no. 22, pp. 5476–5479, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Zhou, C. Benda, S. Duzinger et al., “Generation of induced pluripotent stem cells from urine,” Journal of the American Society of Nephrology, vol. 22, no. 7, pp. 1221–1228, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Aasen, A. Raya, M. J. Barrero et al., “Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes,” Nature Biotechnology, vol. 26, no. 11, pp. 1276–1284, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Warlich, J. Kuehle, T. Cantz et al., “Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming,” Molecular Therapy, vol. 19, no. 4, pp. 782–789, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. K. Okita, T. Ichisaka, and S. Yamanaka, “Generation of germline-competent induced pluripotent stem cells,” Nature, vol. 448, no. 7151, pp. 313–317, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Cyranoski, “Stem cells cruise to clinic,” Nature, vol. 494, no. 7438, p. 413, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Lin, R. Ambasudhan, X. Yuan et al., “A chemical platform for improved induction of human iPSCs,” Nature Methods, vol. 6, no. 11, pp. 805–808, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Zhou, S. Wu, J. Y. Joo et al., “Generation of induced pluripotent stem cells using recombinant proteins,” Cell Stem Cell, vol. 4, no. 5, pp. 381–384, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Bayart and O. Cohen-Haguenauer, “Technological overview of iPS induction from human adult somatic cells,” Current Gene Therapy, vol. 13, no. 2, pp. 73–92, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Lister, M. Pelizzola, Y. S. Kida et al., “Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells,” Nature, vol. 471, no. 7336, pp. 68–73, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. T. S. Mikkelsen, J. Hanna, X. Zhang et al., “Dissecting direct reprogramming through integrative genomic analysis,” Nature, vol. 454, no. 7200, pp. 49–55, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. J. M. Polo, E. Anderssen, R. M. Walsh et al., “A molecular roadmap of reprogramming somatic cells into iPS cells,” Cell, vol. 151, no. 7, pp. 1617–1632, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. B. Papp and K. Plath, “Epigenetics of reprogramming to induced pluripotency,” Cell, vol. 152, no. 6, pp. 1324–1343, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Pick, Y. Stelzer, O. Bar-Nur, Y. Mayshar, A. Eden, and N. Benvenisty, “Clone- and gene-specific aberrations of parental imprinting in human induced pluripotent stem cells,” Stem Cells, vol. 27, no. 11, pp. 2686–2690, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. U. Ben-David, N. Benvenisty, and Y. Mayshar, “Genetic instability in human induced pluripotent stem cells: classification of causes and possible safeguards,” Cell Cycle, vol. 9, no. 23, pp. 4603–4604, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. S. M. Hussein, N. N. Batada, S. Vuoristo et al., “Copy number variation and selection during reprogramming to pluripotency,” Nature, vol. 471, no. 7336, pp. 58–62, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. O. Bar-Nur, H. A. Russ, S. Efrat, and N. Benvenisty, “Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells,” Cell Stem Cell, vol. 9, no. 1, pp. 17–23, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. J. M. Polo, S. Liu, M. E. Figueroa et al., “Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells,” Nature Biotechnology, vol. 28, no. 8, pp. 848–855, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. E. A. Vaskova, A. E. Stekleneva, S. P. Medvedev, and S. M. Zakian, “‘Epigenetic memory’ phenomenon in induced pluripotent stem cells,” Acta Naturae, vol. 5, no. 19, pp. 15–21, 2013. View at Google Scholar · View at Scopus
  34. K. Kim, A. Doi, B. Wen et al., “Epigenetic memory in induced pluripotent stem cells,” Nature, vol. 467, no. 7313, pp. 285–290, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. Y. Ohi, H. Qin, C. Hong et al., “Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells,” Nature Cell Biology, vol. 13, no. 5, pp. 541–549, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Giorgetti, N. Montserrat, T. Aasen et al., “Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2,” Cell Stem Cell, vol. 5, no. 4, pp. 353–357, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. H. Liu, Z. Ye, Y. Kim, S. Sharkis, and Y.-Y. Jang, “Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes,” Hepatology, vol. 51, no. 5, pp. 1810–1819, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. L. Ikonomou and D. N. Kotton, “Derivation of endodermal progenitors from pluripotent stem cells,” Journal of Cellular Physiology, 2014. View at Publisher · View at Google Scholar
  39. X. Zhong, C. Gutierrez, T. Xue et al., “Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs,” Nature Communications, vol. 5, article 4047, 2014. View at Publisher · View at Google Scholar
  40. M. Khan, K. Agarwal, M. Loutfi, and A. Kamal, “Present and possible therapies for age-related macular degeneration,” ISRN Ophthalmology, vol. 2014, Article ID 608390, 7 pages, 2014. View at Publisher · View at Google Scholar
  41. H. Kamao, M. Mandai, S. Okamoto et al., “Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application,” Stem Cell Reports, vol. 2, no. 2, pp. 205–218, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. J. Assawachananont, M. Mandai, S. Okamoto et al., “Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice,” Stem Cell Reports, vol. 2, no. 5, pp. 662–674, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. M. Haruta, Y. Sasai, H. Kawasaki et al., “In vitro and in vivo characterization of pigment epithelial cells differentiated from primate embryonic stem cells,” Investigative Ophthalmology & Visual Science, vol. 45, no. 3, pp. 1020–1025, 2004. View at Google Scholar
  44. A. Haase, R. Olmer, K. Schwanke et al., “Generation of induced pluripotent stem cells from human cord blood,” Cell Stem Cell, vol. 5, no. 4, pp. 434–441, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. P. C. Alguire and B. M. Mathes, “Skin biopsy techniques for the internist,” Journal of General Internal Medicine, vol. 13, no. 1, pp. 46–54, 1998. View at Publisher · View at Google Scholar · View at Scopus
  46. W. E. Lowry, L. Richter, R. Yachechko et al., “Generation of human induced pluripotent stem cells from dermal fibroblasts,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 8, pp. 2883–2888, 2008. View at Publisher · View at Google Scholar · View at Scopus
  47. A. Saxena, J. E. Fish, M. D. White et al., “Stromal cell-derived factor-1α is cardioprotective after myocardial infarction,” Circulation, vol. 117, no. 17, pp. 2224–2231, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. K. D. Salazar, S. M. Lankford, and A. R. Brody, “Mesenchymal stem cells produce Wnt isoforms and TGF-β1 that mediate proliferation and procollagen expression by lung fibroblasts,” American Journal of Physiology: Lung Cellular and Molecular Physiology, vol. 297, no. 5, pp. L1002–L1011, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. Y. Kumada and S. Zhang, “Significant type I and type III collagen production from human periodontal ligament fibroblasts in 3d peptide scaffolds without extra growth factors,” PLoS ONE, vol. 5, no. 4, Article ID e10305, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. A. Somers, J.-C. Jean, C. A. Sommer et al., “Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette,” Stem Cells, vol. 28, no. 10, pp. 1728–1740, 2010. View at Publisher · View at Google Scholar · View at Scopus
  51. K. Streckfuss-Bömeke, F. Wolf, A. Azizian et al., “Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts,” European Heart Journal, vol. 34, no. 33, pp. 2618–2629, 2013. View at Publisher · View at Google Scholar · View at Scopus
  52. P. Samavarchi-Tehrani, A. Golipour, L. David et al., “Functional genomics reveals a BMP-Driven mesenchymal-to-Epithelial transition in the initiation of somatic cell reprogramming,” Cell Stem Cell, vol. 7, no. 1, pp. 64–77, 2010. View at Publisher · View at Google Scholar · View at Scopus
  53. L. M. Souza, T. C. Boone, J. Gabrilove et al., “Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells,” Science, vol. 232, no. 4746, pp. 61–65, 1986. View at Publisher · View at Google Scholar · View at Scopus
  54. Z. M. Szczepiorkowski, J. L. Winters, N. Bandarenko et al., “Guidelines on the use of therapeutic apheresis in clinical practice—evidence-based approach from the apheresis applications committee of the American Society for Apheresis,” Journal of Clinical Apheresis, vol. 25, no. 3, pp. 83–177, 2010. View at Publisher · View at Google Scholar · View at Scopus
  55. A. F. Cashen, H. M. Lazarus, and S. M. Devine, “Mobilizing stem cells from normal donors: is it possible to improve upon G-CSF?” Bone Marrow Transplantation, vol. 39, no. 10, pp. 577–588, 2007. View at Publisher · View at Google Scholar · View at Scopus
  56. T. Serwold, K. Hochedlinger, M. A. Inlay, R. Jaenisch, and I. L. Weissman, “Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes,” The Journal of Immunology, vol. 179, no. 2, pp. 928–938, 2007. View at Publisher · View at Google Scholar · View at Scopus
  57. J. Staerk, M. M. Dawlaty, Q. Gao et al., “Reprogramming of human peripheral blood cells to induced pluripotent stem cells,” Cell Stem Cell, vol. 7, no. 1, pp. 20–24, 2010. View at Publisher · View at Google Scholar · View at Scopus
  58. R. K. Merling, C. L. Sweeney, U. Choi et al., “Transgene-free iPSCs generated from small volume peripheral blood nonmobilized CD34+ cells,” Blood, vol. 121, no. 14, pp. e98–e107, 2013. View at Publisher · View at Google Scholar · View at Scopus
  59. L. Ye, M. O. Muench, N. Fusaki et al., “Blood cell-derived induced pluripotent stem cells free of reprogramming factors generated by Sendai viral vectors,” Stem Cells Translational Medicine, vol. 2, no. 8, pp. 558–566, 2013. View at Publisher · View at Google Scholar · View at Scopus
  60. H.-K. Tan, C.-X. D. Toh, D. Ma et al., “Human finger-prick induced pluripotent stem cells facilitate the development of stem cell banking,” Stem Cells Translational Medicine, vol. 3, no. 5, pp. 586–598, 2014. View at Publisher · View at Google Scholar · View at Scopus
  61. T. Murohara, H. Ikeda, J. Duan et al., “Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization,” The Journal of Clinical Investigation, vol. 105, no. 11, pp. 1527–1536, 2000. View at Publisher · View at Google Scholar · View at Scopus
  62. Y. Xue, X. Cai, L. Wang et al., “Generating a non-integrating human induced pluripotent stem cell bank from urine-derived cells,” PLoS ONE, vol. 8, no. 8, Article ID e70573, 2013. View at Publisher · View at Google Scholar · View at Scopus
  63. L. Wang, L. Wang, W. Huang et al., “Generation of integration-free neural progenitor cells from cells in human urine,” Nature Methods, vol. 10, no. 1, pp. 84–89, 2013. View at Publisher · View at Google Scholar · View at Scopus
  64. J. Gareri and G. Koren, “Prenatal hair development: implications for drug exposure determination,” Forensic Science International, vol. 196, no. 1–3, pp. 27–31, 2010. View at Publisher · View at Google Scholar · View at Scopus
  65. V. A. Randall and N. V. Botchkareva, The Biology of Hair Growth, William Andrew, Norwich, NY, USA, 2009.
  66. G. Cotsarelis, “Epithelial stem cells: a folliculocentric view,” Journal of Investigative Dermatology, vol. 126, no. 7, pp. 1459–1468, 2006. View at Publisher · View at Google Scholar · View at Scopus
  67. Y. Amoh, L. Li, K. Katsuoka, S. Penman, and R. M. Hoffman, “Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 15, pp. 5530–5534, 2005. View at Publisher · View at Google Scholar · View at Scopus
  68. H. Yu, D. Fang, S. M. Kumar et al., “Isolation of a novel population of multipotent adult stem cells from human hair follicles,” The American Journal of Pathology, vol. 168, no. 6, pp. 1879–1888, 2006. View at Publisher · View at Google Scholar · View at Scopus
  69. R. Paus and K. Foitzik, “In search of the “hair cycle clock”: a guided tour,” Differentiation, vol. 72, no. 9-10, pp. 489–511, 2004. View at Publisher · View at Google Scholar · View at Scopus
  70. T. Aasen and J. C. I. Belmonte, “Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells,” Nature Protocols, vol. 5, no. 2, pp. 371–382, 2010. View at Publisher · View at Google Scholar · View at Scopus
  71. A. Gandarillas and F. M. Watt, “c-Myc promotes differentiation of human epidermal stem cells,” Genes and Development, vol. 11, no. 21, pp. 2869–2882, 1997. View at Publisher · View at Google Scholar · View at Scopus
  72. J. A. Segre, C. Bauer, and E. Fuchs, “Klf4 is a transcription factor required for establishing the barrier function of the skin,” Nature Genetics, vol. 22, no. 4, pp. 356–360, 1999. View at Publisher · View at Google Scholar · View at Scopus
  73. L. Linta, M. Stockmann, K. N. Kleinhans et al., “Rat embryonic fibroblasts improve reprogramming of human keratinocytes into induced pluripotent stem cells,” Stem Cells and Development, vol. 21, no. 6, pp. 965–976, 2012. View at Publisher · View at Google Scholar · View at Scopus
  74. Y. Piao, S. S. Hung, S. Y. Lim, R. C. Wong, and M. S. Ko, “Efficient generation of integration-free human induced pluripotent stem cells from keratinocytes by simple transfection of episomal vectors,” Stem Cells Translational Medicine, vol. 3, no. 7, pp. 787–791, 2014. View at Google Scholar
  75. C. A. Squier and M. J. Kremer, “Biology of oral mucosa and esophagus,” Journal of the National Cancer Institute. Monographs, no. 29, pp. 7–15, 2001. View at Google Scholar · View at Scopus
  76. A. Hermann, R. Gastl, S. Liebau et al., “Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells,” Journal of Cell Science, vol. 117, no. 19, pp. 4411–4422, 2004. View at Publisher · View at Google Scholar · View at Scopus
  77. S. Espejel, G. R. Roll, K. J. McLaughlin et al., “Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice,” The Journal of Clinical Investigation, vol. 120, no. 9, pp. 3120–3126, 2010. View at Publisher · View at Google Scholar · View at Scopus
  78. M.-J. Kim, M. J. Son, M.-Y. Son et al., “Generation of human induced pluripotent stem cells from osteoarthritis patient-derived synovial cells,” Arthritis & Rheumatism, vol. 63, no. 10, pp. 3010–3021, 2011. View at Publisher · View at Google Scholar · View at Scopus
  79. Y. Oda, Y. Yoshimura, H. Ohnishi et al., “Induction of pluripotent stem cells from human third molar mesenchymal stromal cells,” Journal of Biological Chemistry, vol. 285, no. 38, pp. 29270–29278, 2010. View at Publisher · View at Google Scholar · View at Scopus